Ankrd28 MGI Mouse Gene Detail - MGI:2145661

Symbol

Ankrd28
Name

ankyrin repeat domain 28
Synonyms

E430019N21Rik

Feature Type

protein coding gene
IDs

MGI:2145661
NCBI Gene: 105522
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr14:31420725-31552608 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 19.40 cM
Mapping Data

2 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145661	protein coding gene	Chr14:31418687-31552608 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021134	protein coding gene	Chr14:24894924-25029742 (-)
A/J	MGP_AJ_G0021082	protein coding gene	Chr14:23958943-24091304 (-)
AKR/J	MGP_AKRJ_G0021059	protein coding gene	Chr14:25084393-25216001 (-)
BALB/cJ	MGP_BALBcJ_G0021086	protein coding gene	Chr14:24094129-24228207 (-)
C3H/HeJ	MGP_C3HHeJ_G0020869	protein coding gene	Chr14:24954603-25090960 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021518	protein coding gene	Chr14:25874754-26016466 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019081	protein coding gene	Chr14:24026978-24166055 (-)
CAST/EiJ	MGP_CASTEiJ_G0020394	protein coding gene	Chr14:24750115-24890182 (-)
CBA/J	MGP_CBAJ_G0020836	protein coding gene	Chr14:26852867-26986909 (-)
DBA/2J	MGP_DBA2J_G0020958	protein coding gene	Chr14:23993496-24127468 (-)
FVB/NJ	MGP_FVBNJ_G0020942	protein coding gene	Chr14:23947163-24079309 (-)
LP/J	MGP_LPJ_G0021027	protein coding gene	Chr14:25219808-25354287 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020968	protein coding gene	Chr14:26111808-26256877 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021551	protein coding gene	Chr14:24852107-24991007 (-)
PWK/PhJ	MGP_PWKPhJ_G0020142	protein coding gene	Chr14:23458684-23596872 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019966	protein coding gene	Chr14:24466443-24607044 (-)
WSB/EiJ	MGP_WSBEiJ_G0020449	protein coding gene	Chr14:24926569-25062990 (-)

Human Ortholog

ANKRD28, ankyrin repeat domain 28

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANKRD28, ankyrin repeat domain 28
Synonyms

CFAP79, FAP79, PITK, PPP1R65
Links

HGNC:29024

NCBI Gene ID: 23243

neXtProt AC: NX_O15084

UniProt: O15084
Chr Location

3p25.1; chr3:15667236-15859814 (-) GRCh38

MGI Vertebrate Homology

Ankrd28 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANKRD28
Gene Tree

Ankrd28

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

1
Gene trapped

19
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ankrd28

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All Sequences

85
RefSeq

22
UniProt

6
CCDS

CCDS36858.1

Ensembl

ENSMUSG00000014496 (Evidence)
NCBI Gene

105522

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014496	Ensembl Gene Model \| MGI Sequence Detail	131884	C57BL/6J	± kb
transcript	ENSMUST00000227863	Ensembl \| MGI Sequence Detail	6616	Not Applicable
polypeptide	ENSMUSP00000153992	Ensembl \| MGI Sequence Detail	1083	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004047 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

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All nucleic 15

cDNA 15

Microarray probesets 7

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MGI:2145679

Summaries

All 31

Gene Ontology 2

Phenotypes 6
Earliest

J:34960 Chambers DM, et al., Isolation and mapping of novel mouse brain cDNA clones containing trinucleotide repeats, and demonstration of novel alleles in recombinant inbred strains. Genome Res. 1996 Aug;6(8):715-23
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ankrd28:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128001	Chr14:31552610-31552690 (-)	-42 bp
Tssr128000	Chr14:31552359-31552397 (-)	230 bp
Tssr127999	Chr14:31503953-31503980 (-)	48,641 bp
Tssr127998	Chr14:31503870-31503892 (-)	48,727 bp
Tssr127997	Chr14:31503619-31503688 (-)	48,954 bp
Tssr127996	Chr14:31503590-31503618 (-)	49,004 bp
Tssr127995	Chr14:31503574-31503589 (-)	49,026 bp
Tssr127994	Chr14:31503544-31503553 (-)	49,059 bp
Tssr127993	Chr14:31503445-31503458 (-)	49,156 bp
Tssr127992	Chr14:31503405-31503428 (-)	49,191 bp
Tssr127991	Chr14:31503380-31503397 (-)	49,219 bp
Tssr127990	Chr14:31503358-31503369 (-)	49,244 bp
Tssr127989	Chr14:31502955-31502971 (-)	49,645 bp
Tssr127988	Chr14:31502929-31502944 (-)	49,671 bp
Tssr127987	Chr14:31502885-31502920 (-)	49,705 bp
Tssr127986	Chr14:31464784-31464795 (-)	87,818 bp
Tssr127985	Chr14:31450971-31450974 (-)	101,635 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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