Prkaa1 MGI Mouse Gene Detail - MGI:2145955 - protein kinase, AMP-activated, alpha 1 catalytic subunit

Symbol

Prkaa1
Name

protein kinase, AMP-activated, alpha 1 catalytic subunit
Synonyms

AMPKalpha1, C130083N04Rik

Feature Type

protein coding gene
IDs

MGI:2145955
NCBI Gene: 105787
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:5173343-5211380 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 1.99 cM
Mapping Data

3 experiments

SNPs within 2kb

1114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145955	protein coding gene	Chr15:5172641-5211380 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021692	protein coding gene	Chr15:2049347-2089996 (+)
A/J	MGP_AJ_G0021653	protein coding gene	Chr15:2059593-2099124 (+)
AKR/J	MGP_AKRJ_G0021631	protein coding gene	Chr15:2033601-2075649 (+)
BALB/cJ	MGP_BALBcJ_G0021660	protein coding gene	Chr15:1983324-2023660 (+)
C3H/HeJ	MGP_C3HHeJ_G0021436	protein coding gene	Chr15:2060380-2099224 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022099	protein coding gene	Chr15:2152713-2195227 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019636	protein coding gene	Chr15:1797435-1834892 (+)
CAST/EiJ	MGP_CASTEiJ_G0020952	protein coding gene	Chr15:2047196-2086798 (+)
CBA/J	MGP_CBAJ_G0021405	protein coding gene	Chr15:2178963-2226862 (+)
DBA/2J	MGP_DBA2J_G0021529	protein coding gene	Chr15:1992544-2030765 (+)
FVB/NJ	MGP_FVBNJ_G0021507	protein coding gene	Chr15:1929880-1968679 (+)
LP/J	MGP_LPJ_G0021597	protein coding gene	Chr15:1984053-2024200 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021532	protein coding gene	Chr15:2312112-2356248 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022122	protein coding gene	Chr15:2044264-2087042 (+)
PWK/PhJ	MGP_PWKPhJ_G0020695	protein coding gene	Chr15:2008529-2050981 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020533	protein coding gene	Chr15:2005462-2041151 (+)
WSB/EiJ	MGP_WSBEiJ_G0021008	protein coding gene	Chr15:1982687-2025219 (+)

Human Ortholog

PRKAA1, protein kinase AMP-activated catalytic subunit alpha 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKAA1, protein kinase AMP-activated catalytic subunit alpha 1
Synonyms

AMPK, AMPKa1, AMPK alpha 1
Links

HGNC:9376

NCBI Gene ID: 5562

neXtProt AC: NX_Q13131

UniProt: Q13131
Chr Location

5p13.1; chr5:40759389-40798374 (-) GRCh38

MGI Vertebrate Homology

Prkaa1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRKAA1
Gene Tree

Prkaa1

Diseases

3 with human PRKAA1 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				colon cancer IDs colon cancer DOID:219 ICD10CM:C18 ICD9CM:153 ICD9CM:153.9 MESH:D003110 NCI:C9242 UMLS_CUI:C0007102
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

27 phenotypes from 1 allele in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
235 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Endonuclease-mediated

7
Gene trapped

18
Targeted

9
Transgenic

1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show reduced muscle cell glucose uptake, anemia, reticulocytosis, splenomegaly, increased erythrocyte turnover and plasma erythropoietin levels, and female subfertility associated with decreased litter size, reduced ovulation rate and a hyperandrogenic response.

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All GO Annotations

165
GO References

32

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

32
cDNA Data

84
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prkaa1

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All Sequences

47
RefSeq

6
UniProt

3
CCDS

CCDS49574.1

Ensembl

ENSMUSG00000050697 (Evidence)
NCBI Gene

105787

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050697	Ensembl Gene Model \| MGI Sequence Detail	38038	C57BL/6J	± kb
transcript	ENSMUST00000051186	Ensembl \| MGI Sequence Detail	4655	Not Applicable
polypeptide	ENSMUSP00000063166	Ensembl \| MGI Sequence Detail	559	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013218 5'-AMP-activated protein kinase catalytic subunit alpha-1

(term hierarchy)
PDB

5UFU
EC

2.7.11.1, 2.7.11.26, 2.7.11.31
InterPro Domains

IPR039137 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal

IPR032270 AMPK, C-terminal adenylate sensor domain

IPR028375 KA1 domain/Ssp2, C-terminal

IPR049020 PRKAA1/2, autoinhibitory domain

IPR028797 PRKAA1, UBA-like autoinhibitory domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q5EG47 1 site, 1 O-linked glycan (1 site)

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All nucleic 86

cDNA 85

Primer pair 1

Microarray probesets 4

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MGI:2146014, MGI:2146120

Summaries

All 463

Developmental Gene Expression 43

Gene Ontology 32

Phenotypes 235
Earliest

J:54164 Turnley AM, et al., Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem. 1999 Apr;72(4):1707-16
Latest

J:358517 Li M, et al., AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res. 2024 Oct;34(10):683-706

TSS for Prkaa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130442	Chr15:5173343-5173378 (+)	18 bp
Tssr130443	Chr15:5182634-5182638 (+)	9,293 bp
Tssr130444	Chr15:5209229-5209246 (+)	35,895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24