Dip2b MGI Mouse Gene Detail - MGI:2145977 - disco interacting protein 2 homolog B

Symbol

Dip2b
Name

disco interacting protein 2 homolog B
Synonyms

mKIAA1463

Feature Type

protein coding gene
IDs

MGI:2145977
NCBI Gene: 239667
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr15:99936545-100117354 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.14 cM
Mapping Data

2 experiments

SNPs within 2kb

4155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145977	protein coding gene	Chr15:99935119-100117355 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022347	protein coding gene	Chr15:101947089-102144777 (+)
A/J	MGP_AJ_G0022305	protein coding gene	Chr15:97884292-98069505 (+)
AKR/J	MGP_AKRJ_G0022281	protein coding gene	Chr15:100885427-101069837 (+)
BALB/cJ	MGP_BALBcJ_G0022311	protein coding gene	Chr15:98045782-98229662 (+)
C3H/HeJ	MGP_C3HHeJ_G0022079	protein coding gene	Chr15:100956596-101155233 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022756	protein coding gene	Chr15:105747344-105939668 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020282	protein coding gene	Chr15:93739336-93925995 (+)
CAST/EiJ	MGP_CASTEiJ_G0021603	protein coding gene	Chr15:101821659-102033019 (+)
CBA/J	MGP_CBAJ_G0022048	protein coding gene	Chr15:109365628-109564045 (+)
DBA/2J	MGP_DBA2J_G0022175	protein coding gene	Chr15:97302624-97482522 (+)
FVB/NJ	MGP_FVBNJ_G0022155	protein coding gene	Chr15:96299526-96484441 (+)
LP/J	MGP_LPJ_G0022246	protein coding gene	Chr15:102088152-102280055 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022175	protein coding gene	Chr15:113227211-113427823 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022771	protein coding gene	Chr15:101001266-101188518 (+)
PWK/PhJ	MGP_PWKPhJ_G0021342	protein coding gene	Chr15:97451188-97651280 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021177	protein coding gene	Chr15:100849977-101039851 (+)
WSB/EiJ	MGP_WSBEiJ_G0021654	protein coding gene	Chr15:101529419-101723720 (+)

Human Ortholog

DIP2B, disco interacting protein 2 homolog B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DIP2B, disco interacting protein 2 homolog B
Links

HGNC:29284

NCBI Gene ID: 57609

neXtProt AC: NX_Q9P265

UniProt: Q9P265
Chr Location

12q13.12; chr12:50504985-50748657 (+) GRCh38

MGI Vertebrate Homology

Dip2b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DIP2B
Gene Tree

Dip2b

Diseases

1 with human DIP2B associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder IDs autosomal dominant intellectual developmental disorder DOID:0060307 OMIM:PS156200 ORDO:178469

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

82
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Dip2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

138 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

784
Tissues

52
cDNA Data

96
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dip2b

ZFIN dip2ba

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All Sequences

59
RefSeq

14
UniProt

2
CCDS

CCDS27831.1, CCDS49731.1

Ensembl

ENSMUSG00000023026 (Evidence)
NCBI Gene

239667

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023026	Ensembl Gene Model \| MGI Sequence Detail	180810	C57BL/6J	± kb
transcript	ENSMUST00000100203	Ensembl \| MGI Sequence Detail	8914	Not Applicable
polypeptide	ENSMUSP00000097777	Ensembl \| MGI Sequence Detail	1574	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006484 disco-interacting protein 2 homolog B

(term hierarchy)
InterPro Domains

IPR045851 AMP-binding enzyme, C-terminal domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

IPR037337 Dip2-like domain

IPR010506 DMAP1-binding domain
GlyGen

Q3UH60 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 97

cDNA 96

Primer pair 1

Microarray probesets 3

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MGI:2146097

Summaries

All 62

Developmental Gene Expression 5

Diseases 1

Gene Ontology 4

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dip2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133080	Chr15:99936516-99936550 (+)	-12 bp
Tssr133081	Chr15:99936555-99936602 (+)	34 bp
Tssr133082	Chr15:99936628-99936689 (+)	114 bp
Tssr133083	Chr15:99958126-99958139 (+)	21,588 bp
Tssr4715	Chr15:99961489-99961495 (+)	24,947 bp
Tssr133084	Chr15:99965382-99965394 (+)	28,843 bp
Tssr133085	Chr15:99972985-99973003 (+)	36,449 bp
Tssr4716	Chr15:99982092-99982129 (+)	45,566 bp
Tssr133086	Chr15:100052050-100052095 (+)	115,528 bp
Tssr133087	Chr15:100052260-100052292 (+)	115,731 bp
Tssr133088	Chr15:100054855-100054860 (+)	118,313 bp
Tssr133089	Chr15:100079318-100079329 (+)	142,779 bp
Tssr133090	Chr15:100080154-100080195 (+)	143,630 bp
Tssr133091	Chr15:100096520-100096535 (+)	159,983 bp
Tssr133092	Chr15:100097161-100097177 (+)	160,624 bp
Tssr133093	Chr15:100099981-100099988 (+)	163,440 bp
Tssr133094	Chr15:100115078-100115082 (+)	178,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24