Card10 MGI Mouse Gene Detail - MGI:2146012 - caspase recruitment domain family, member 10

Symbol

Card10
Name

caspase recruitment domain family, member 10
Synonyms

Bimp1, CARMA3

Feature Type

protein coding gene
IDs

MGI:2146012
NCBI Gene: 105844
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:78659338-78687242 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

2 experiments

SNPs within 2kb

872 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146012	protein coding gene	Chr15:78659323-78687261 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022052	protein coding gene	Chr15:78990026-79019131 (-)
A/J	MGP_AJ_G0022013	protein coding gene	Chr15:76278501-76305689 (-)
AKR/J	MGP_AKRJ_G0021988	protein coding gene	Chr15:78387574-78425789 (-)
BALB/cJ	MGP_BALBcJ_G0022019	protein coding gene	Chr15:76252574-76280154 (-)
C3H/HeJ	MGP_C3HHeJ_G0021790	protein coding gene	Chr15:78394693-78422449 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022462	protein coding gene	Chr15:82103146-82130468 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019992	protein coding gene	Chr15:72774985-72803323 (-)
CAST/EiJ	MGP_CASTEiJ_G0021311	protein coding gene	Chr15:79084075-79113763 (-)
CBA/J	MGP_CBAJ_G0021755	protein coding gene	Chr15:84633102-84662184 (-)
DBA/2J	MGP_DBA2J_G0021884	protein coding gene	Chr15:75765110-75792305 (-)
FVB/NJ	MGP_FVBNJ_G0021862	protein coding gene	Chr15:74772534-74801928 (-)
LP/J	MGP_LPJ_G0021952	protein coding gene	Chr15:79199281-79227657 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021882	protein coding gene	Chr15:89807772-89836411 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022476	protein coding gene	Chr15:78415433-78443674 (-)
PWK/PhJ	MGP_PWKPhJ_G0021053	protein coding gene	Chr15:75761330-75788960 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020890	protein coding gene	Chr15:78201598-78230031 (-)
WSB/EiJ	MGP_WSBEiJ_G0021363	protein coding gene	Chr15:78779387-78810793 (-)

Human Ortholog

CARD10, caspase recruitment domain family member 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CARD10, caspase recruitment domain family member 10
Synonyms

BIMP1, CARMA3, IMD89
Links

HGNC:16422

NCBI Gene ID: 29775

neXtProt AC: NX_Q9BWT7

UniProt: Q9BWT7
Chr Location

22q13.1; chr22:37490362-37519542 (-) GRCh38

MGI Vertebrate Homology

Card10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CARD10
Gene Tree

Card10

Diseases

1 with human CARD10 associations

				Human Disease	Mouse Models
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Card10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a null allele exhibit partial penetrance of anencephaly and subsequent perinatal lethality of anencephalic embryos.

less

All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

10
cDNA Data

24
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

less

All Sequences

40
RefSeq

6
UniProt

2
CCDS

CCDS27623.2

Ensembl

ENSMUSG00000033170 (Evidence)
NCBI Gene

105844

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033170	Ensembl Gene Model \| MGI Sequence Detail	27905	C57BL/6J	± kb
transcript	ENSMUST00000164826	Ensembl \| MGI Sequence Detail	4726	Not Applicable
polypeptide	ENSMUSP00000129513	Ensembl \| MGI Sequence Detail	1070	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000005033 caspase recruitment domain-containing protein 10

(term hierarchy)
InterPro Domains

IPR042140 CARD10, CARD domain

IPR001315 CARD domain

IPR011029 Death-like domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

less

All nucleic 24

cDNA 24

Microarray probesets 3

Summaries

All 58

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:331190 Wu Y, et al., Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis. Biochem Biophys Res Commun. 2021 Dec 3;581:81-88

TSS for Card10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135288	Chr15:78688564-78688578 (-)	-1,329 bp
Tssr135287	Chr15:78687215-78687250 (-)	9 bp
Tssr135286	Chr15:78687085-78687120 (-)	139 bp
Tssr135285	Chr15:78687070-78687084 (-)	165 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24