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Washc5 Gene Detail
Summary
  • Symbol
    Washc5
  • Name
    WASH complex subunit 5
  • Synonyms
    E430025E21Rik, mKIAA0196, strumpellin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146110
    NCBI Gene: 223593
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:59203846-59246016 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 25.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1302 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146110
 protein coding gene Chr15:59203712-59246043 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021883
 protein coding gene Chr15:58549241-58594510 (-)
A/J MGP_AJ_G0021843
 protein coding gene Chr15:56275439-56318124 (-)
AKR/J MGP_AKRJ_G0021824
 protein coding gene Chr15:57825695-57869305 (-)
BALB/cJ MGP_BALBcJ_G0021850
 protein coding gene Chr15:56487949-56529699 (-)
C3H/HeJ MGP_C3HHeJ_G0021624
 protein coding gene Chr15:57956069-57998832 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022289
 protein coding gene Chr15:60810230-60853560 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019826
 protein coding gene Chr15:53346908-53392319 (-)
CAST/EiJ MGP_CASTEiJ_G0021141
 protein coding gene Chr15:58624701-58682236 (-)
CBA/J MGP_CBAJ_G0021593
 protein coding gene Chr15:62940323-62985162 (-)
DBA/2J MGP_DBA2J_G0021717
 protein coding gene Chr15:56180562-56222884 (-)
FVB/NJ MGP_FVBNJ_G0021695
 protein coding gene Chr15:55229852-55272260 (-)
LP/J MGP_LPJ_G0021787
 protein coding gene Chr15:58419307-58462855 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021719
 protein coding gene Chr15:67969766-68023287 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022312
 protein coding gene Chr15:58230073-58271770 (-)
PWK/PhJ MGP_PWKPhJ_G0020886
 protein coding gene Chr15:56184838-56240018 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020723
 protein coding gene Chr15:58022507-58065095 (-)
WSB/EiJ MGP_WSBEiJ_G0021196
 protein coding gene Chr15:58239577-58284366 (-)



Homology
more
  • Human Ortholog
    WASHC5, WASH complex subunit 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WASHC5, WASH complex subunit 5
  • Synonyms
    KIAA0196, RTSC, RTSC1, SPG8
  • Links
    NCBI Gene ID: 9897
    neXtProt AC: NX_Q12768
    UniProt: Q12768

  • Chr Location
    8q24.13; chr8:125024260-125091819 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human WASHC5 associations

Human Disease Mouse Models
      
IDs
 View 1 "NOT" model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal coat color and melanocyte stem cells but enlarged, clustered WASH- and WAFL-positive vesicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1087
  • Tissues
    39
  • cDNA Data
    206
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022350 Ensembl Gene Model | MGI Sequence Detail 42171 C57BL/6J ±  kb
    transcript ENSMUST00000022976 Ensembl | MGI Sequence Detail 4033 Not Applicable  
    polypeptide ENSMUSP00000022976 Ensembl | MGI Sequence Detail 1159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 206
      cDNA 206

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146270
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 16
      Phenotypes 39
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory