Alg10b MGI Mouse Gene Detail - MGI:2146159 - ALG10 alpha-1,2-glucosyltransferase

Symbol

Alg10b
Name

ALG10 alpha-1,2-glucosyltransferase
Synonyms

Deaf1, LOC380959, nse5

Feature Type

protein coding gene
IDs

MGI:2146159
NCBI Gene: 380959
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:90108514-90117674 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 45.07 cM
Mapping Data

2 experiments

SNPs within 2kb

447 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146159	protein coding gene	Chr15:90108506-90117674 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022243	protein coding gene	Chr15:91467894-91474081 (+)
A/J	MGP_AJ_G0022202	protein coding gene	Chr15:87951726-87957969 (+)
AKR/J	MGP_AKRJ_G0022177	protein coding gene	Chr15:90546913-90553156 (+)
BALB/cJ	MGP_BALBcJ_G0022208	protein coding gene	Chr15:88061464-88067707 (+)
C3H/HeJ	MGP_C3HHeJ_G0021978	protein coding gene	Chr15:90573914-90580157 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022653	protein coding gene	Chr15:94780285-94786528 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020178	protein coding gene	Chr15:84125169-84131399 (+)
CAST/EiJ	MGP_CASTEiJ_G0021500	protein coding gene	Chr15:91346983-91353191 (+)
CBA/J	MGP_CBAJ_G0021945	protein coding gene	Chr15:98023028-98029271 (+)
DBA/2J	MGP_DBA2J_G0022072	protein coding gene	Chr15:87403043-87409286 (+)
FVB/NJ	MGP_FVBNJ_G0022051	protein coding gene	Chr15:86453944-86460187 (+)
LP/J	MGP_LPJ_G0022143	protein coding gene	Chr15:91622067-91628310 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022071	protein coding gene	Chr15:102409589-102415759 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022668	protein coding gene	Chr15:90639700-90645943 (+)
PWK/PhJ	MGP_PWKPhJ_G0021241	protein coding gene	Chr15:87445533-87451776 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021075	protein coding gene	Chr15:90377995-90384243 (+)
WSB/EiJ	MGP_WSBEiJ_G0021549	protein coding gene	Chr15:91118193-91124318 (+)

Human Ortholog

ALG10, ALG10 alpha-1,2-glucosyltransferase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALG10, ALG10 alpha-1,2-glucosyltransferase
Synonyms

ALG10A, DIE2, KCR1
Links

HGNC:23162

NCBI Gene ID: 84920

neXtProt AC: NX_Q5BKT4

UniProt: Q5BKT4
Chr Location

12p11.1; chr12:34022377-34029694 (+) GRCh38

Human Ortholog

ALG10B, ALG10 alpha-1,2-glucosyltransferase B
Synonyms

ALG10, KCR1
Links

HGNC:31088

NCBI Gene ID: 144245

neXtProt AC: NX_Q5I7T1

UniProt: Q5I7T1
Chr Location

12q12; chr12:38316687-38329721 (+) GRCh38

MGI Vertebrate Homology

Alg10b stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALG10, ALG10B
Protein SuperFamily

Alpha1_2_glucosyltferase_Alg10
Gene Tree

Alg10b

Diseases

1 with Alg10b mouse models; 1 with human ALG10B associations

Human Disease

Mouse Models

nonsyndromic deafness

IDs

View 1 model

long QT syndrome 2

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

32 phenotypes from 3 alleles in 4 genetic backgrounds
1 images
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Alg10b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU induced allele exhibit deafness associated with cochlear outer hair cell degeneration.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

120
cDNA Data

17
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS27757.1

Ensembl

ENSMUSG00000075470 (Evidence)
NCBI Gene

380959

			Length	Strain/Species	Flank
genomic	ENSMUSG00000075470	Ensembl Gene Model \| MGI Sequence Detail	9161	C57BL/6J	± kb
transcript	ENSMUST00000100309	Ensembl \| MGI Sequence Detail	6644	Not Applicable
polypeptide	ENSMUSP00000097882	Ensembl \| MGI Sequence Detail	474	Not Applicable

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UniProt

3 Sequences
EC

2.4.1.256
InterPro Domains

IPR016900 Alpha-2-glucosyltransferase Alg10

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 4

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MGI:2146197, MGI:2146311, MGI:2671653, MGI:2685763, MGI:3035095

Summaries

All 53

Developmental Gene Expression 2

Diseases 2

Gene Ontology 6

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Alg10b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132702	Chr15:90108480-90108494 (+)	-27 bp
Tssr132703	Chr15:90108496-90108577 (+)	23 bp
Tssr132704	Chr15:90108651-90108664 (+)	144 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24