Dock10 MGI Mouse Gene Detail - MGI:2146320 - dedicator of cytokinesis 10

Symbol

Dock10
Name

dedicator of cytokinesis 10
Synonyms

9330153B10Rik, A630054M16Rik, Jr4, Jr5, mKIAA0694, ZIZ3, Zizimin3

Feature Type

protein coding gene
IDs

MGI:2146320
NCBI Gene: 210293
Alliance

gene page
Transcription Start Sites

24 TSS

Sequence Map

Chr1:80478790-80736244 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 41.41 cM
Mapping Data

2 experiments

SNPs within 2kb

7748 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146320	protein coding gene	Chr1:80478785-80736482 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016211	protein coding gene	Chr1:81322515-81594654 (-)
A/J	MGP_AJ_G0016194	protein coding gene	Chr1:78458705-78717751 (-)
AKR/J	MGP_AKRJ_G0016151	protein coding gene	Chr1:80601549-80865896 (-)
BALB/cJ	MGP_BALBcJ_G0016149	protein coding gene	Chr1:78536400-78788115 (-)
C3H/HeJ	MGP_C3HHeJ_G0015979	protein coding gene	Chr1:80960271-81227103 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016602	protein coding gene	Chr1:84483678-84765190 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014322	protein coding gene	Chr1:73773934-74023163 (-)
CAST/EiJ	MGP_CASTEiJ_G0015565	protein coding gene	Chr1:80329266-80607134 (-)
CBA/J	MGP_CBAJ_G0015953	protein coding gene	Chr1:87183172-87480697 (-)
DBA/2J	MGP_DBA2J_G0016054	protein coding gene	Chr1:77756677-78009999 (-)
FVB/NJ	MGP_FVBNJ_G0016057	protein coding gene	Chr1:76893798-77148411 (-)
LP/J	MGP_LPJ_G0016127	protein coding gene	Chr1:82475083-82748174 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016077	protein coding gene	Chr1:90466830-90752789 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016649	protein coding gene	Chr1:80752281-81019250 (-)
PWK/PhJ	MGP_PWKPhJ_G0015350	protein coding gene	Chr1:77182554-77445484 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015128	protein coding gene	Chr1:79994078-80248314 (-)
WSB/EiJ	MGP_WSBEiJ_G0015625	protein coding gene	Chr1:80495184-80774168 (-)

Human Ortholog

DOCK10, dedicator of cytokinesis 10

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOCK10, dedicator of cytokinesis 10
Synonyms

DRIP2, Nbla10300, ZIZ3
Links

HGNC:23479

NCBI Gene ID: 55619

neXtProt AC: NX_Q96BY6

UniProt: Q96BY6
Chr Location

2q36.2; chr2:224765090-225042468 (-) GRCh38

MGI Vertebrate Homology

Dock10 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: DOCK10
Gene Tree

Dock10

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Dock10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

140 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. Homozygous KO also leads to a thinner spleen marginal zone B cell region and a decreased thymic CD8+ T cell percentage.

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

37
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock10

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All Sequences

124
RefSeq

56
UniProt

8
CCDS

CCDS48297.1, CCDS78626.1

Ensembl

ENSMUSG00000038608 (Evidence)
NCBI Gene

210293

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038608	Ensembl Gene Model \| MGI Sequence Detail	257455	C57BL/6J	± kb
transcript	ENSMUST00000077946	Ensembl \| MGI Sequence Detail	7198	Not Applicable
polypeptide	ENSMUSP00000077099	Ensembl \| MGI Sequence Detail	2187	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000006617 dedicator of cytokinesis protein 10

(term hierarchy)
PDB

8I5F, 8I5V, 8I5W
InterPro Domains

IPR016024 Armadillo-type fold

IPR027007 C2 DOCK-type domain

IPR035892 C2 domain superfamily

IPR026791 Dedicator of cytokinesis

IPR021816 Dedicator of cytokinesis C/D, N-terminal

IPR043161 Dedicator of cytokinesis, C-terminal, lobe A

IPR043162 Dedicator of cytokinesis, C-terminal, lobe C

IPR037809 Dedicator of cytokinesis D, C2 domain

IPR027357 DOCKER domain

IPR046769 DOCKER, Lobe A

IPR046770 DOCKER, Lobe B

IPR046773 DOCKER, Lobe C

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain
GlyGen

Q8BZN6 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 4

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MGI:2441818

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 15
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dock10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12495	Chr1:80736408-80736426 (-)	-173 bp
Tssr12494	Chr1:80736379-80736397 (-)	-144 bp
Tssr12493	Chr1:80736253-80736275 (-)	-20 bp
Tssr12492	Chr1:80736233-80736249 (-)	3 bp
Tssr12491	Chr1:80736198-80736216 (-)	37 bp
Tssr12490	Chr1:80733767-80733769 (-)	2,476 bp
Tssr12489	Chr1:80733525-80733538 (-)	2,712 bp
Tssr12488	Chr1:80704070-80704074 (-)	32,172 bp
Tssr12487	Chr1:80693422-80693426 (-)	42,820 bp
Tssr12486	Chr1:80693198-80693208 (-)	43,041 bp
Tssr12485	Chr1:80688111-80688119 (-)	48,129 bp
Tssr12484	Chr1:80687216-80687233 (-)	49,019 bp
Tssr12483	Chr1:80687092-80687118 (-)	49,139 bp
Tssr12482	Chr1:80643025-80643072 (-)	93,195 bp
Tssr12481	Chr1:80642969-80643022 (-)	93,248 bp
Tssr12480	Chr1:80642924-80642936 (-)	93,314 bp
Tssr12479	Chr1:80642010-80642020 (-)	94,229 bp
Tssr12478	Chr1:80609165-80609184 (-)	127,069 bp
Tssr12477	Chr1:80609112-80609139 (-)	127,118 bp
Tssr12476	Chr1:80583536-80583552 (-)	152,700 bp
Tssr12475	Chr1:80576752-80576756 (-)	159,490 bp
Tssr12474	Chr1:80551902-80551917 (-)	184,334 bp
Tssr12473	Chr1:80527566-80527570 (-)	208,676 bp
Tssr12472	Chr1:80521960-80521980 (-)	214,274 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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