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Slc7a4 Gene Detail
Summary
  • Symbol
    Slc7a4
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
  • Synonyms
    MGC:27672
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146512
    NCBI Gene: 224022
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17389882-17394619 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146512
 protein coding gene Chr16:17389882-17401078 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022586
 protein coding gene Chr16:14731433-14735148 (-)
A/J MGP_AJ_G0022547
 protein coding gene Chr16:14002479-14006194 (-)
AKR/J MGP_AKRJ_G0022524
 protein coding gene Chr16:14548611-14552326 (-)
BALB/cJ MGP_BALBcJ_G0022550
 protein coding gene Chr16:14155005-14158726 (-)
C3H/HeJ MGP_C3HHeJ_G0022317
 protein coding gene Chr16:14700987-14704729 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023001
 protein coding gene Chr16:14967914-14971656 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020521
 protein coding gene Chr16:14069565-14074575 (-)
CAST/EiJ MGP_CASTEiJ_G0021845
 protein coding gene Chr16:14601935-14605650 (-)
CBA/J MGP_CBAJ_G0022288
 protein coding gene Chr16:15638428-15642170 (-)
DBA/2J MGP_DBA2J_G0022418
 protein coding gene Chr16:13920518-13924261 (-)
FVB/NJ MGP_FVBNJ_G0022394
 protein coding gene Chr16:13962103-13965846 (-)
LP/J MGP_LPJ_G0022485
 protein coding gene Chr16:14492144-14495859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022415
 protein coding gene Chr16:15330957-15334784 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023012
 protein coding gene Chr16:14494875-14498590 (-)
PWK/PhJ MGP_PWKPhJ_G0021588
 protein coding gene Chr16:14174849-14178591 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021416
 protein coding gene Chr16:14470995-14474702 (-)
WSB/EiJ MGP_WSBEiJ_G0021892
 protein coding gene Chr16:14487593-14491308 (-)



Homology
more
  • Human Ortholog
    SLC7A4, solute carrier family 7 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A4, solute carrier family 7 member 4
  • Synonyms
    CAT-4, CAT4, HCAT3, VH
  • Links
    NCBI Gene ID: 6545
    neXtProt AC: NX_O43246
    UniProt: O43246

  • Chr Location
    22q11.21; chr22:21028718-21032840 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1017
  • Tissues
    141
  • cDNA Data
    34
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 224022 NCBI Gene Model | MGI Sequence Detail 4738 C57BL/6J ±  kb
transcript NM_001416939 RefSeq | MGI Sequence Detail 3565 C57BL/6  
polypeptide Q8BLQ7 UniProt | EBI | MGI Sequence Detail 635 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 34
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:348704 Vong KI, et al., Risk of meningomyelocele mediated by the common 22q11.2 deletion. Science. 2024 May 3;384(6695):584-590
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory