Clic6 MGI Mouse Gene Detail - MGI:2146607 - chloride intracellular channel 6

Symbol

Clic6
Name

chloride intracellular channel 6
Synonyms

5730466J16Rik, CLIC1L

Feature Type

protein coding gene
IDs

MGI:2146607
NCBI Gene: 209195
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr16:92295035-92338129 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 53.64 cM
Mapping Data

2 experiments

SNPs within 2kb

1475 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146607	protein coding gene	Chr16:92282624-92338131 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023058	protein coding gene	Chr16:93571671-93633637 (+)
A/J	MGP_AJ_G0023026	protein coding gene	Chr16:89190721-89247530 (+)
AKR/J	MGP_AKRJ_G0022996	protein coding gene	Chr16:91913702-91976288 (+)
BALB/cJ	MGP_BALBcJ_G0023028	protein coding gene	Chr16:89720342-89776104 (+)
C3H/HeJ	MGP_C3HHeJ_G0022789	protein coding gene	Chr16:92452126-92507955 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023475	protein coding gene	Chr16:96564418-96623352 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020977	protein coding gene	Chr16:86872987-86932170 (+)
CAST/EiJ	MGP_CASTEiJ_G0022308	protein coding gene	Chr16:93041683-93100661 (+)
CBA/J	MGP_CBAJ_G0022758	protein coding gene	Chr16:100708328-100768513 (+)
DBA/2J	MGP_DBA2J_G0022892	protein coding gene	Chr16:89098139-89154091 (+)
FVB/NJ	MGP_FVBNJ_G0022866	protein coding gene	Chr16:88222171-88278374 (+)
LP/J	MGP_LPJ_G0022962	protein coding gene	Chr16:93266310-93323822 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022887	protein coding gene	Chr16:105208669-105269000 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023493	protein coding gene	Chr16:92414477-92471041 (+)
PWK/PhJ	MGP_PWKPhJ_G0022053	protein coding gene	Chr16:89295775-89352577 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021883	protein coding gene	Chr16:91987390-92048080 (+)
WSB/EiJ	MGP_WSBEiJ_G0022360	protein coding gene	Chr16:92659878-92718074 (+)

Human Ortholog

CLIC6, chloride intracellular channel 6

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLIC6, chloride intracellular channel 6
Synonyms

CLIC1L
Links

HGNC:2065

NCBI Gene ID: 54102

neXtProt AC: NX_Q96NY7

UniProt: Q96NY7
Chr Location

21q22.12; chr21:34668994-34718227 (+) GRCh38

MGI Vertebrate Homology

Clic6 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLIC6
Gene Tree

Clic6

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References

4 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
76 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

2
Spontaneous

1
Targeted

10
Genomic Mutations

9 involving Clic6
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

970
Tissues

229
cDNA Data

29
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS28338.1

Ensembl

ENSMUSG00000022949 (Evidence)
NCBI Gene

209195

			Length	Strain/Species	Flank
genomic	209195	NCBI Gene Model \| MGI Sequence Detail	43095	C57BL/6J	± kb
transcript	NM_172469	RefSeq \| MGI Sequence Detail	3743	C57BL/6
polypeptide	Q8BHB9	UniProt \| EBI \| MGI Sequence Detail	596	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005579 chloride intracellular channel protein 6

(term hierarchy)
PDB

6ERY, 6ERZ
EC

1.8.-.-
InterPro Domains

IPR036282 Glutathione S-transferase, C-terminal domain superfamily

IPR010987 Glutathione S-transferase, C-terminal-like

IPR040079 Glutathione transferase family

IPR002946 Intracellular chloride channel

IPR036249 Thioredoxin-like superfamily

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All nucleic 34

cDNA 30

Primer pair 3

Other 1

Microarray probesets 5

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MGI:2146524

Summaries

All 111

Developmental Gene Expression 9

Diseases 4

Gene Ontology 7

Phenotypes 76
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077

TSS for Clic6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139477	Chr16:92294973-92294982 (+)	-57 bp
Tssr139478	Chr16:92295001-92295006 (+)	-31 bp
Tssr139479	Chr16:92295010-92295063 (+)	2 bp
Tssr139480	Chr16:92295098-92295107 (+)	68 bp
Tssr139481	Chr16:92295496-92295506 (+)	466 bp
Tssr139482	Chr16:92295561-92295630 (+)	561 bp
Tssr139483	Chr16:92295653-92295712 (+)	648 bp
Tssr139484	Chr16:92315941-92315965 (+)	20,918 bp
Tssr139485	Chr16:92335874-92335875 (+)	40,840 bp
Tssr139486	Chr16:92336767-92336770 (+)	41,734 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24