Gpsm3 MGI Mouse Gene Detail - MGI:2146785 - G-protein signalling modulator 3 (AGS3-like, C. elegans)

Symbol

Gpsm3
Name

G-protein signalling modulator 3 (AGS3-like, C. elegans)
Synonyms

AGS4

Feature Type

protein coding gene
IDs

MGI:2146785
NCBI Gene: 106512
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr17:34808780-34810728 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.17 cM
Mapping Data

1 experiment

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146785	protein coding gene	Chr17:34808780-34810728 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023577	protein coding gene	Chr17:34662729-34664677 (+)
A/J	MGP_AJ_G0023539	protein coding gene	Chr17:33487583-33489531 (+)
AKR/J	MGP_AKRJ_G0023504	protein coding gene	Chr17:33904694-33906642 (+)
BALB/cJ	MGP_BALBcJ_G0023543	protein coding gene	Chr17:33635537-33637485 (+)
C3H/HeJ	MGP_C3HHeJ_G0023303	protein coding gene	Chr17:34297239-34299187 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023983	protein coding gene	Chr17:35984104-35986052 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021462	protein coding gene	Chr17:31376274-31378228 (+)
CAST/EiJ	MGP_CASTEiJ_G0022803	protein coding gene	Chr17:34370790-34372738 (+)
CBA/J	MGP_CBAJ_G0023281	protein coding gene	Chr17:37514878-37516826 (+)
DBA/2J	MGP_DBA2J_G0023409	protein coding gene	Chr17:32774158-32776106 (+)
FVB/NJ	MGP_FVBNJ_G0023376	protein coding gene	Chr17:32680718-32682668 (+)
LP/J	MGP_LPJ_G0023487	protein coding gene	Chr17:34939430-34941378 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023399	protein coding gene	Chr17:36403115-36405063 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024026	protein coding gene	Chr17:34209914-34211862 (+)
PWK/PhJ	MGP_PWKPhJ_G0022551	protein coding gene	Chr17:31706757-31708707 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022368	protein coding gene	Chr17:32199538-32201487 (+)
WSB/EiJ	MGP_WSBEiJ_G0022864	protein coding gene	Chr17:34302087-34304037 (+)

Human Ortholog

GPSM3, G protein signaling modulator 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPSM3, G protein signaling modulator 3
Synonyms

AGS4, C6orf9, G18, G18.1a, G18.1b, G18.2, NG1
Links

HGNC:13945

NCBI Gene ID: 63940

neXtProt AC: NX_Q9Y4H4

UniProt: Q9Y4H4
Chr Location

6p21.32; chr6:32190766-32195523 (-) GRCh38

MGI Vertebrate Homology

Gpsm3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPSM3
Gene Tree

Gpsm3

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Gene trapped

8
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit a reduction in the number, viability, and chemotactic function of monocytes and show decreased susceptibility to collagen antibody-induced arthritis.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

56
cDNA Data

43
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

2
UniProt

4
CCDS

CCDS37589.1

Ensembl

ENSMUSG00000034786 (Evidence)
NCBI Gene

106512

			Length	Strain/Species	Flank
genomic	106512	NCBI Gene Model \| MGI Sequence Detail	1949	C57BL/6J	± kb
transcript	NM_134116	RefSeq \| MGI Sequence Detail	1359	C57BL/6
polypeptide	Q3U1Z5	UniProt \| EBI \| MGI Sequence Detail	159	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008206 G-protein-signaling modulator 3

(term hierarchy)
InterPro Domains

IPR003109 GoLoco motif

IPR042888 G-protein-signaling modulator 3

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 44

Genomic 1

cDNA 43

Microarray probesets 3

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 15
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpsm3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144040	Chr17:34808773-34808804 (+)	9 bp
Tssr144041	Chr17:34808806-34808887 (+)	67 bp
Tssr144042	Chr17:34808888-34808902 (+)	115 bp
Tssr144043	Chr17:34808928-34808939 (+)	154 bp
Tssr144044	Chr17:34809030-34809078 (+)	274 bp
Tssr144045	Chr17:34809089-34809116 (+)	323 bp
Tssr144046	Chr17:34809136-34809179 (+)	378 bp
Tssr144047	Chr17:34809383-34809422 (+)	623 bp
Tssr144048	Chr17:34809424-34809438 (+)	651 bp
Tssr144049	Chr17:34809477-34809513 (+)	715 bp
Tssr144050	Chr17:34809767-34809803 (+)	1,005 bp
Tssr144051	Chr17:34809808-34809821 (+)	1,035 bp
Tssr144052	Chr17:34809825-34809870 (+)	1,068 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24