Safb2 MGI Mouse Gene Detail - MGI:2146808 - scaffold attachment factor B2

Symbol

Safb2
Name

scaffold attachment factor B2

Feature Type

protein coding gene
IDs

MGI:2146808
NCBI Gene: 224902
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:56867965-56891585 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.39 cM
Mapping Data

1 experiment

SNPs within 2kb

416 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2146808	protein coding gene	Chr17:56867965-56891673 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023928	protein coding gene	Chr17:58263741-58287849 (-)
A/J	MGP_AJ_G0023886	protein coding gene	Chr17:56671451-56695322 (-)
AKR/J	MGP_AKRJ_G0023855	protein coding gene	Chr17:57370497-57394599 (-)
BALB/cJ	MGP_BALBcJ_G0023887	protein coding gene	Chr17:56488525-56512143 (-)
C3H/HeJ	MGP_C3HHeJ_G0023651	protein coding gene	Chr17:58093950-58125932 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024333	protein coding gene	Chr17:60520392-60545851 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021779	protein coding gene	Chr17:53146067-53169955 (-)
CAST/EiJ	MGP_CASTEiJ_G0023133	protein coding gene	Chr17:58381913-58405852 (-)
CBA/J	MGP_CBAJ_G0023627	protein coding gene	Chr17:62891190-62915391 (-)
DBA/2J	MGP_DBA2J_G0023755	protein coding gene	Chr17:55371495-55395835 (-)
FVB/NJ	MGP_FVBNJ_G0023721	protein coding gene	Chr17:54908551-54934471 (-)
LP/J	MGP_LPJ_G0023837	protein coding gene	Chr17:58949695-58974439 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023749	protein coding gene	Chr17:62375180-62405356 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024377	protein coding gene	Chr17:57729377-57754915 (-)
PWK/PhJ	MGP_PWKPhJ_G0022879	protein coding gene	Chr17:54728960-54753614 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022690	protein coding gene	Chr17:54499009-54526005 (-)
WSB/EiJ	MGP_WSBEiJ_G0023199	protein coding gene	Chr17:58338373-58362099 (-)

Human Ortholog

SAFB2, scaffold attachment factor B2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SAFB2, scaffold attachment factor B2
Links

HGNC:21605

NCBI Gene ID: 9667

neXtProt AC: NX_Q14151

UniProt: Q14151
Chr Location

19p13.3; chr19:5586999-5624046 (-) GRCh38

MGI Vertebrate Homology

Safb2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SAFB2
Gene Tree

Safb2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

1
Gene trapped

15
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male homozyous mutant mice exhibit an increase in testis weight and an increased number of Sertoli cells.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

15
cDNA Data

19
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SAFB

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All Sequences

114
RefSeq

37
UniProt

11
CCDS

CCDS28907.2

Ensembl

ENSMUSG00000042625 (Evidence)
NCBI Gene

224902

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042625	Ensembl Gene Model \| MGI Sequence Detail	23621	C57BL/6J	± kb
transcript	ENSMUST00000075510	Ensembl \| MGI Sequence Detail	3277	Not Applicable
polypeptide	ENSMUSP00000074953	Ensembl \| MGI Sequence Detail	991	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000014433 scaffold attachment factor B2

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003034 SAP domain

IPR036361 SAP domain superfamily

IPR051738 Scaffold Attachment Factor and Modulators

IPR034781 Scaffold attachment factor B1/2, RNA binding domain
GlyGen

Q80YR5 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 19

Microarray probesets 6

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MGI:3035169

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Safb2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148821	Chr17:56891594-56891605 (-)	-15 bp
Tssr148820	Chr17:56891507-56891568 (-)	47 bp
Tssr148819	Chr17:56891309-56891323 (-)	269 bp
Tssr148818	Chr17:56878500-56878513 (-)	13,078 bp
Tssr148817	Chr17:56878234-56878264 (-)	13,336 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24