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Ift140 Gene Detail
Summary
  • Symbol
    Ift140
  • Name
    intraflagellar transport 140
  • Synonyms
    mKIAA0590, Tce5, Wdtc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146906
    NCBI Gene: 106633
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25235056-25318461 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146906
 protein coding gene Chr17:25235056-25318469 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023336
 protein coding gene Chr17:24047267-24135473 (+)
A/J MGP_AJ_G0023295
 protein coding gene Chr17:23385440-23468188 (+)
AKR/J MGP_AKRJ_G0023261
 protein coding gene Chr17:23471471-23559013 (+)
BALB/cJ MGP_BALBcJ_G0023300
 protein coding gene Chr17:23578593-23661872 (+)
C3H/HeJ MGP_C3HHeJ_G0023060
 protein coding gene Chr17:23839974-23927418 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023743
 protein coding gene Chr17:25108354-25199868 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021218
 protein coding gene Chr17:20837469-20923992 (+)
CAST/EiJ MGP_CASTEiJ_G0022562
 protein coding gene Chr17:23691114-23775767 (+)
CBA/J MGP_CBAJ_G0023035
 protein coding gene Chr17:25972704-26057301 (+)
DBA/2J MGP_DBA2J_G0023165
 protein coding gene Chr17:22975635-23056968 (+)
FVB/NJ MGP_FVBNJ_G0023135
 protein coding gene Chr17:22693347-22775639 (+)
LP/J MGP_LPJ_G0023242
 protein coding gene Chr17:24348965-24435053 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023154
 protein coding gene Chr17:25643451-25727066 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023782
 protein coding gene Chr17:23758523-23840258 (+)
PWK/PhJ MGP_PWKPhJ_G0022311
 protein coding gene Chr17:21727697-21813548 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022129
 protein coding gene Chr17:21819770-21903743 (+)
WSB/EiJ MGP_WSBEiJ_G0022625
 protein coding gene Chr17:23827319-23910218 (+)



Homology
more
  • Human Ortholog
    IFT140, intraflagellar transport 140
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFT140, intraflagellar transport 140
  • Synonyms
    c305C8.4, c380F5.1, gs114, MZSDS, RP80, SRTD9, WDTC2
  • Links
    NCBI Gene ID: 9742
    neXtProt AC: NX_Q96RY7
    UniProt: Q96RY7

  • Chr Location
    16p13.3; chr16:1510427-1612072 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ift140 mouse models; 2 with human IFT140 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    88 phenotypes from 4 alleles in 6 genetic backgrounds
    16 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter knock-out allele die at mid-gestation. Mice homozygous for an ENU-induced mutation exhibit cardiovascular defects and situs abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    18
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    29
  • cDNA Data
    9
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106633 NCBI Gene Model | MGI Sequence Detail 83406 C57BL/6J ±  kb
    transcript NM_001410317 RefSeq | MGI Sequence Detail 5834 C57BL/6  
    polypeptide E9PY46 UniProt | EBI | MGI Sequence Detail 1464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008932 intraflagellar transport protein 140
      (term hierarchy)
    • InterPro Domains
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      E9PY46 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 9
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1930191
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory