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Arhgap28 Gene Detail
Summary
  • Symbol
    Arhgap28
  • Name
    Rho GTPase activating protein 28
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147003
    NCBI Gene: 268970
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:68149708-68311115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 38.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147003
 protein coding gene Chr17:68149701-68311185 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023993
 protein coding gene Chr17:70130009-70307323 (-)
A/J MGP_AJ_G0023951
 protein coding gene Chr17:68009700-68174419 (-)
AKR/J MGP_AKRJ_G0023920
 protein coding gene Chr17:68961846-69129136 (-)
BALB/cJ MGP_BALBcJ_G0023952
 protein coding gene Chr17:67958113-68124893 (-)
C3H/HeJ MGP_C3HHeJ_G0023716
 protein coding gene Chr17:69865628-70035397 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024398
 protein coding gene Chr17:72752442-72925955 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021844
 protein coding gene Chr17:63949200-64105237 (-)
CAST/EiJ MGP_CASTEiJ_G0023198
 protein coding gene Chr17:70234885-70421864 (-)
CBA/J MGP_CBAJ_G0023692
 protein coding gene Chr17:75674335-75868852 (-)
DBA/2J MGP_DBA2J_G0023820
 protein coding gene Chr17:66713325-66881176 (-)
FVB/NJ MGP_FVBNJ_G0023786
 protein coding gene Chr17:66213825-66373651 (-)
LP/J MGP_LPJ_G0023902
 protein coding gene Chr17:70854204-71030427 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023814
 protein coding gene Chr17:75673361-75856216 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024442
 protein coding gene Chr17:69416738-69595890 (-)
PWK/PhJ MGP_PWKPhJ_G0022944
 protein coding gene Chr17:66044404-66206286 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022755
 protein coding gene Chr17:66143425-66310180 (-)
WSB/EiJ MGP_WSBEiJ_G0023264
 protein coding gene Chr17:70159379-70331453 (-)



Homology
more
  • Human Ortholog
    ARHGAP28, Rho GTPase activating protein 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP28, Rho GTPase activating protein 28
  • Links
    NCBI Gene ID: 79822
    UniProt: Q9P2N2

  • Chr Location
    18p11.31; chr18:6729716-6915716 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ARHGAP28 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal bone length and ossification.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    13
  • cDNA Data
    67
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024043 Ensembl Gene Model | MGI Sequence Detail 161408 C57BL/6J ±  kb
    transcript ENSMUST00000024840 Ensembl | MGI Sequence Detail 5322 Not Applicable  
    polypeptide ENSMUSP00000024840 Ensembl | MGI Sequence Detail 729 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 67
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147083
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory