Slc39a3 MGI Mouse Gene Detail - MGI:2147269 - solute carrier family 39 (zinc transporter), member 3

Symbol

Slc39a3
Name

solute carrier family 39 (zinc transporter), member 3
Synonyms

MGC:7461, zip3

Feature Type

protein coding gene
IDs

MGI:2147269
NCBI Gene: 106947
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:80864374-80873169 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

235 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147269	protein coding gene	Chr10:80864372-80873260 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017532	protein coding gene	Chr10:81704866-81713748 (-)
A/J	MGP_AJ_G0017510	protein coding gene	Chr10:78823258-78832130 (-)
AKR/J	MGP_AKRJ_G0017471	protein coding gene	Chr10:80986367-80995282 (-)
BALB/cJ	MGP_BALBcJ_G0017472	protein coding gene	Chr10:79038233-79047125 (-)
C3H/HeJ	MGP_C3HHeJ_G0017295	protein coding gene	Chr10:81068838-81077706 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017926	protein coding gene	Chr10:84512759-84524493 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015615	protein coding gene	Chr10:75028504-75037598 (-)
CAST/EiJ	MGP_CASTEiJ_G0016862	protein coding gene	Chr10:81308620-81317302 (-)
CBA/J	MGP_CBAJ_G0017267	protein coding gene	Chr10:87809169-87818013 (-)
DBA/2J	MGP_DBA2J_G0017373	protein coding gene	Chr10:78017855-78026784 (-)
FVB/NJ	MGP_FVBNJ_G0017367	protein coding gene	Chr10:77258572-77267405 (-)
LP/J	MGP_LPJ_G0017444	protein coding gene	Chr10:82157059-82166423 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017393	protein coding gene	Chr10:89680698-89689592 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017967	protein coding gene	Chr10:80980012-80988875 (-)
PWK/PhJ	MGP_PWKPhJ_G0016643	protein coding gene	Chr10:77915699-77925921 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016433	protein coding gene	Chr10:79929005-79937912 (-)
WSB/EiJ	MGP_WSBEiJ_G0016922	protein coding gene	Chr10:81017678-81026365 (-)

Human Ortholog

SLC39A3, solute carrier family 39 member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC39A3, solute carrier family 39 member 3
Synonyms

ZIP-3, ZIP3
Links

HGNC:17128

NCBI Gene ID: 29985

neXtProt AC: NX_Q9BRY0

UniProt: Q9BRY0
Chr Location

19p13.3; chr19:2732204-2740076 (-) GRCh38

MGI Vertebrate Homology

Slc39a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC39A3
Gene Tree

Slc39a3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Slc39a3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Homozygous null mice stressed with a zinc-deficient diet during pregnancy or at weaning exhibit a subtle increase in the sensitivity to abnormal morphogenesis of the embryo and to depletion of thymic pre-T cells, respectively.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

952
Tissues

152
cDNA Data

55
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a3

ZFIN slc39a3

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All Sequences

58
RefSeq

10
UniProt

2
CCDS

CCDS24041.1

Ensembl

ENSMUSG00000046822 (Evidence)
NCBI Gene

106947

			Length	Strain/Species	Flank
genomic	106947	NCBI Gene Model \| MGI Sequence Detail	8796	C57BL/6J	± kb
transcript	NM_134135	RefSeq \| MGI Sequence Detail	3687	C57BL/6
polypeptide	Q99K24	UniProt \| EBI \| MGI Sequence Detail	317	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015130 zinc transporter ZIP3

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 56

cDNA 56

Microarray probesets 5

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:337461 Elgheznawy A, et al., Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Front Immunol. 2023;14:1197894

TSS for Slc39a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98551	Chr10:80873134-80873173 (-)	15 bp
Tssr98550	Chr10:80873092-80873129 (-)	58 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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