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Wdr74 Gene Detail
Summary
  • Symbol
    Wdr74
  • Name
    WD repeat domain 74
  • Synonyms
    5730436H21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147427
    NCBI Gene: 107071
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8713191-8717988 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    168 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147427
 protein coding gene Chr19:8713159-8717988 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024804
 protein coding gene Chr19:6007841-6012623 (+)
A/J MGP_AJ_G0024772
 protein coding gene Chr19:5687402-5692601 (+)
AKR/J MGP_AKRJ_G0024747
 protein coding gene Chr19:5776212-5780932 (+)
BALB/cJ MGP_BALBcJ_G0024772
 protein coding gene Chr19:5790359-5795371 (+)
C3H/HeJ MGP_C3HHeJ_G0024538
 protein coding gene Chr19:5856927-5861743 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025219
 protein coding gene Chr19:6126850-6132139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022648
 protein coding gene Chr19:5929271-5933882 (+)
CAST/EiJ MGP_CASTEiJ_G0024011
 protein coding gene Chr19:5504420-5508989 (+)
CBA/J MGP_CBAJ_G0024512
 protein coding gene Chr19:6242861-6247438 (+)
DBA/2J MGP_DBA2J_G0024639
 protein coding gene Chr19:5518261-5522838 (+)
FVB/NJ MGP_FVBNJ_G0024606
 protein coding gene Chr19:5593765-5598484 (+)
LP/J MGP_LPJ_G0024726
 protein coding gene Chr19:5896297-5901016 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024633
 protein coding gene Chr19:6112866-6117588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025268
 protein coding gene Chr19:5820511-5825742 (+)
PWK/PhJ MGP_PWKPhJ_G0023756
 protein coding gene Chr19:5183562-5188147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023561
 protein coding gene Chr19:5418156-5422741 (+)
WSB/EiJ MGP_WSBEiJ_G0024073
 protein coding gene Chr19:5784367-5790066 (+)



Homology
more
  • Human Ortholog
    WDR74, WD repeat domain 74
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR74, WD repeat domain 74
  • Synonyms
    Nsa1
  • Links
    NCBI Gene ID: 54663
    neXtProt AC: NX_Q6RFH5
    UniProt: Q6RFH5

  • Chr Location
    11q12.3; chr11:62832342-62841809 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    10
  • cDNA Data
    63
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042729 Ensembl Gene Model | MGI Sequence Detail 4798 C57BL/6J ±  kb
transcript ENSMUST00000049424 Ensembl | MGI Sequence Detail 1204 Not Applicable  
polypeptide ENSMUSP00000043315 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 63
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory