About   Help   FAQ
Kazald1 Gene Detail
Summary
  • Symbol
    Kazald1
  • Name
    Kazal-type serine peptidase inhibitor domain 1
  • Synonyms
    Bono1, Igfbp-rp10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147606
    NCBI Gene: 107250
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:45063680-45067728 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147606
 protein coding gene Chr19:45063404-45067728 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025184
 protein coding gene Chr19:44623940-44628242 (+)
A/J MGP_AJ_G0025161
 protein coding gene Chr19:42475889-42479942 (+)
AKR/J MGP_AKRJ_G0025129
 protein coding gene Chr19:43836784-43840818 (+)
BALB/cJ MGP_BALBcJ_G0025155
 protein coding gene Chr19:42526626-42530675 (+)
C3H/HeJ MGP_C3HHeJ_G0024915
 protein coding gene Chr19:44004464-44008496 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025598
 protein coding gene Chr19:45716796-45720839 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023012
 protein coding gene Chr19:41742680-41746773 (+)
CAST/EiJ MGP_CASTEiJ_G0024380
 protein coding gene Chr19:43744630-43748676 (+)
CBA/J MGP_CBAJ_G0024895
 protein coding gene Chr19:48035467-48039499 (+)
DBA/2J MGP_DBA2J_G0025027
 protein coding gene Chr19:42293876-42297922 (+)
FVB/NJ MGP_FVBNJ_G0024988
 protein coding gene Chr19:42063046-42067555 (+)
LP/J MGP_LPJ_G0025113
 protein coding gene Chr19:44570148-44574192 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025019
 protein coding gene Chr19:47414439-47418492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025656
 protein coding gene Chr19:43915986-43920050 (+)
PWK/PhJ MGP_PWKPhJ_G0024129
 protein coding gene Chr19:42201509-42205589 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023933
 protein coding gene Chr19:42607603-42611681 (+)
WSB/EiJ MGP_WSBEiJ_G0024450
 protein coding gene Chr19:44066259-44070300 (+)



Homology
more
  • Human Ortholog
    KAZALD1, Kazal type serine peptidase inhibitor domain 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KAZALD1, Kazal type serine peptidase inhibitor domain 1
  • Synonyms
    BONO1, FKSG28, FKSG40, IGFBP-rP10
  • Links
    NCBI Gene ID: 81621
    neXtProt AC: NX_Q96I82
    UniProt: Q96I82

  • Chr Location
    10q24.31; chr10:101061989-101068131 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    54
  • cDNA Data
    15
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025213 Ensembl Gene Model | MGI Sequence Detail 4049 C57BL/6J ±  kb
transcript ENSMUST00000026234 Ensembl | MGI Sequence Detail 1380 Not Applicable  
polypeptide ENSMUSP00000026234 Ensembl | MGI Sequence Detail 313 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009247 Kazal-type serine protease inhibitor domain-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR011390 Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
    IPR002350 Kazal domain
    IPR036058 Kazal domain superfamily
  • GlyGen
    Q8BJ66 3 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:292644 Whiley PAF, et al., Activin A Determines Steroid Levels and Composition in the Fetal Testis. Endocrinology. 2020 Jul 1;161(7)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory