Otub1 MGI Mouse Gene Detail - MGI:2147616 - OTU domain, ubiquitin aldehyde binding 1

Symbol

Otub1
Name

OTU domain, ubiquitin aldehyde binding 1

Feature Type

protein coding gene
IDs

MGI:2147616
NCBI Gene: 107260
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr19:7175571-7183649 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 5.27 cM
Mapping Data

1 experiment

SNPs within 2kb

231 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147616	protein coding gene	Chr19:7175567-7183681 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024785	protein coding gene	Chr19:4314088-4323490 (-)
A/J	MGP_AJ_G0024752	protein coding gene	Chr19:3965860-3973783 (-)
AKR/J	MGP_AKRJ_G0024725	protein coding gene	Chr19:4100244-4108147 (-)
BALB/cJ	MGP_BALBcJ_G0024752	protein coding gene	Chr19:4085507-4093396 (-)
C3H/HeJ	MGP_C3HHeJ_G0024520	protein coding gene	Chr19:4225864-4233795 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025198	protein coding gene	Chr19:4402231-4410164 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022632	protein coding gene	Chr19:3872205-3877911 (-)
CAST/EiJ	MGP_CASTEiJ_G0023992	protein coding gene	Chr19:4132767-4140696 (-)
CBA/J	MGP_CBAJ_G0024492	protein coding gene	Chr19:4479735-4487660 (-)
DBA/2J	MGP_DBA2J_G0024619	protein coding gene	Chr19:3935807-3943740 (-)
FVB/NJ	MGP_FVBNJ_G0024584	protein coding gene	Chr19:3972550-3981875 (-)
LP/J	MGP_LPJ_G0024705	protein coding gene	Chr19:4169679-4185789 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024614	protein coding gene	Chr19:4366070-4374002 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025246	protein coding gene	Chr19:4242710-4250633 (-)
PWK/PhJ	MGP_PWKPhJ_G0023738	protein coding gene	Chr19:3985315-4003507 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023542	protein coding gene	Chr19:4043664-4051979 (-)
WSB/EiJ	MGP_WSBEiJ_G0024054	protein coding gene	Chr19:4140861-4148783 (-)

Human Ortholog

OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1
Synonyms

HSPC263, OTB1, OTU1
Links

HGNC:23077

NCBI Gene ID: 55611

neXtProt AC: NX_Q96FW1

UniProt: Q96FW1
Chr Location

11q13.1; chr11:63985853-64001811 (+) GRCh38

MGI Vertebrate Homology

Otub1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OTUB1
Protein SuperFamily

Ubiquitin_thioesterase_Otubain
Gene Tree

Otub1

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Phenotype Summary

29 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

2
Gene trapped

11
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die between E14.5 and birth.

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

85
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase otub1

ZFIN otub1a, otub1b

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS29520.1

Ensembl

ENSMUSG00000024767 (Evidence)
NCBI Gene

107260

			Length	Strain/Species	Flank
genomic	107260	NCBI Gene Model \| MGI Sequence Detail	8079	C57BL/6J	± kb
transcript	NM_134150	RefSeq \| MGI Sequence Detail	1677	C57BL/6
polypeptide	Q7TQI3	UniProt \| EBI \| MGI Sequence Detail	271	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012080 ubiquitin thioesterase OTUB1

(term hierarchy)
EC

3.4.19.12
InterPro Domains

IPR003323 OTU domain

IPR038765 Papain-like cysteine peptidase superfamily

IPR019400 Peptidase C65, otubain

IPR042468 Peptidase C65, otubain, subdomain 1

IPR042467 Peptidase C65, otubain, subdomain 2

IPR016615 Ubiquitin thioesterase Otubain
GlyGen

Q7TQI3 1 site, 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 11

Microarray probesets 4

Summaries

All 49

Developmental Gene Expression 7

Gene Ontology 7

Phenotypes 17
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345930 Luo VM, et al., The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2. Mol Cell Biol. 2024 Jan;44(1):1-16

TSS for Otub1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr157941	Chr19:7183626-7183666 (-)	3 bp
Tssr157940	Chr19:7183597-7183607 (-)	47 bp
Tssr157939	Chr19:7179703-7179721 (-)	3,937 bp
Tssr157938	Chr19:7177350-7177367 (-)	6,290 bp
Tssr157937	Chr19:7176293-7176300 (-)	7,352 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24