Lpxn MGI Mouse Gene Detail - MGI:2147677

Symbol

Lpxn
Name

leupaxin
Synonyms

4933402K05Rik, A530083L21Rik

Feature Type

protein coding gene
IDs

MGI:2147677
NCBI Gene: 107321
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:12773557-12811171 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.73 cM
Mapping Data

3 experiments

SNPs within 2kb

1113 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2147677	protein coding gene	Chr19:12773251-12811177 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024915	protein coding gene	Chr19:10287668-10327680 (+)
A/J	MGP_AJ_G0024891	protein coding gene	Chr19:9636861-9673556 (+)
AKR/J	MGP_AKRJ_G0024863	protein coding gene	Chr19:10113439-10147723 (+)
BALB/cJ	MGP_BALBcJ_G0024890	protein coding gene	Chr19:9648419-9683146 (+)
C3H/HeJ	MGP_C3HHeJ_G0024654	protein coding gene	Chr19:10003064-10037644 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025339	protein coding gene	Chr19:10836232-10872136 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022765	protein coding gene	Chr19:10270746-10304327 (+)
CAST/EiJ	MGP_CASTEiJ_G0024123	protein coding gene	Chr19:9568558-9601788 (+)
CBA/J	MGP_CBAJ_G0024628	protein coding gene	Chr19:10937053-10977381 (+)
DBA/2J	MGP_DBA2J_G0024760	protein coding gene	Chr19:9697079-9730127 (+)
FVB/NJ	MGP_FVBNJ_G0024723	protein coding gene	Chr19:9702121-9734870 (+)
LP/J	MGP_LPJ_G0024843	protein coding gene	Chr19:10364618-10399532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024750	protein coding gene	Chr19:10699015-10735110 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025387	protein coding gene	Chr19:10097692-10132545 (+)
PWK/PhJ	MGP_PWKPhJ_G0023872	protein coding gene	Chr19:9150443-9184345 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023676	protein coding gene	Chr19:9254677-9297077 (+)
WSB/EiJ	MGP_WSBEiJ_G0024191	protein coding gene	Chr19:9952971-9989827 (+)

Human Ortholog

LPXN, leupaxin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LPXN, leupaxin
Synonyms

LDPL
Links

HGNC:14061

NCBI Gene ID: 9404

neXtProt AC: NX_O60711

UniProt: O60711
Chr Location

11q12.1; chr11:58526871-58578891 (-) GRCh38

MGI Vertebrate Homology

Lpxn stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LPXN
Protein SuperFamily

Leupaxin
Gene Tree

Lpxn

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Gene trapped

15
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit decreased circulation glucose levels and impaired plasma cell differentiation after stimulation with LPS.

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All GO Annotations

34
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

758
Tissues

50
cDNA Data

22
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

10
UniProt

3
CCDS

CCDS29638.1, CCDS89350.1

Ensembl

ENSMUSG00000024696 (Evidence)
NCBI Gene

107321

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024696	Ensembl Gene Model \| MGI Sequence Detail	37615	C57BL/6J	± kb
transcript	ENSMUST00000025601	Ensembl \| MGI Sequence Detail	1684	Not Applicable
polypeptide	ENSMUSP00000025601	Ensembl \| MGI Sequence Detail	386	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009908 leupaxin

(term hierarchy)
InterPro Domains

IPR017305 Leupaxin/Paxillin/TGFB1I1

IPR001781 Zinc finger, LIM-type

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All nucleic 25

cDNA 23

Primer pair 2

Microarray probesets 3

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MGI:2442455

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lpxn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155355	Chr19:12772325-12772364 (+)	-1,212 bp
Tssr155356	Chr19:12773086-12773096 (+)	-466 bp
Tssr155357	Chr19:12773232-12773261 (+)	-310 bp
Tssr155358	Chr19:12773262-12773275 (+)	-288 bp
Tssr155359	Chr19:12775938-12775953 (+)	2,389 bp
Tssr155360	Chr19:12775988-12776000 (+)	2,437 bp
Tssr155361	Chr19:12778724-12778738 (+)	5,174 bp
Tssr155362	Chr19:12782073-12782084 (+)	8,522 bp
Tssr155363	Chr19:12782222-12782238 (+)	8,673 bp
Tssr155364	Chr19:12782240-12782251 (+)	8,689 bp
Tssr155365	Chr19:12782652-12782699 (+)	9,119 bp
Tssr155366	Chr19:12782712-12782744 (+)	9,171 bp
Tssr155367	Chr19:12783564-12783595 (+)	10,023 bp
Tssr155368	Chr19:12805321-12805335 (+)	31,771 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24