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Tmem132a Gene Detail
Summary
  • Symbol
    Tmem132a
  • Name
    transmembrane protein 132A
  • Synonyms
    6720481D13Rik, Hspa5bp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147810
    NCBI Gene: 98170
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10835186-10847304 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 7.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    344 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147810
 protein coding gene Chr19:10835186-10847569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024859
 protein coding gene Chr19:8232720-8244832 (-)
A/J MGP_AJ_G0024827
 protein coding gene Chr19:7674712-7686804 (-)
AKR/J MGP_AKRJ_G0024802
 protein coding gene Chr19:7974410-7986450 (-)
BALB/cJ MGP_BALBcJ_G0024827
 protein coding gene Chr19:7719701-7731692 (-)
C3H/HeJ MGP_C3HHeJ_G0024593
 protein coding gene Chr19:7863680-7875792 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025275
 protein coding gene Chr19:8585582-8597511 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022702
 protein coding gene Chr19:8091374-8103300 (-)
CAST/EiJ MGP_CASTEiJ_G0024066
 protein coding gene Chr19:7516886-7528459 (-)
CBA/J MGP_CBAJ_G0024567
 protein coding gene Chr19:8635129-8650799 (-)
DBA/2J MGP_DBA2J_G0024694
 protein coding gene Chr19:7679261-7691313 (-)
FVB/NJ MGP_FVBNJ_G0024661
 protein coding gene Chr19:7724443-7736792 (-)
LP/J MGP_LPJ_G0024781
 protein coding gene Chr19:8183830-8195830 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024688
 protein coding gene Chr19:8533443-8546499 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025323
 protein coding gene Chr19:7997207-8009294 (-)
PWK/PhJ MGP_PWKPhJ_G0023811
 protein coding gene Chr19:7133177-7145398 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023616
 protein coding gene Chr19:7178886-7194395 (-)
WSB/EiJ MGP_WSBEiJ_G0024128
 protein coding gene Chr19:7884855-7898843 (-)



Homology
more
  • Human Ortholog
    TMEM132A, transmembrane protein 132A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM132A, transmembrane protein 132A
  • Synonyms
    GBP, HSPA5BP1
  • Links
    NCBI Gene ID: 54972
    neXtProt AC: NX_Q24JP5
    UniProt: Q24JP5

  • Chr Location
    11q12.2; chr11:60924460-60937159 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele die at birth exhibiting a range of malformations, including spina bifida, caudal body truncation, underdeveloped limb buds, forelimb syndactyly, lung and renal defects, and a shortened colon.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    64
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024736 Ensembl Gene Model | MGI Sequence Detail 12119 C57BL/6J ±  kb
    transcript ENSMUST00000025645 Ensembl | MGI Sequence Detail 3657 Not Applicable  
    polypeptide ENSMUSP00000025645 Ensembl | MGI Sequence Detail 1018 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016411 transmembrane protein 132A
      (term hierarchy)
    • InterPro Domains
      IPR026307 Transmembrane protein 132
      IPR031437 Transmembrane protein family 132, middle domain
      IPR031436 Transmembrane protein TMEM132, C-terminal
      IPR031435 Transmembrane protein TMEM132, N-terminal
    • GlyGen
      Q922P8 2 sites, 4 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:355098 Oh SA, et al., TMEM132A regulates Wnt/beta-catenin signaling through stabilizing LRP6 during mouse embryonic development. Cell Commun Signal. 2024 Oct 9;22(1):482
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory