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Atg4a Gene Detail
Summary
  • Symbol
    Atg4a
  • Name
    autophagy related 4A, cysteine peptidase
  • Synonyms
    Apg4a, Autl2, autophagin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147903
    NCBI Gene: 666468
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:139857656-139947266 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 61.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1100 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147903
 protein coding gene ChrX:139854594-139947266 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036140
 protein coding gene ChrX:138534562-138632501 (+)
A/J MGP_AJ_G0036118
 protein coding gene ChrX:137899462-137997561 (+)
AKR/J MGP_AKRJ_G0036043
 protein coding gene ChrX:142328739-142437533 (+)
BALB/cJ MGP_BALBcJ_G0036108
 protein coding gene ChrX:136204215-136297908 (+)
C3H/HeJ MGP_C3HHeJ_G0035817
 protein coding gene ChrX:138532726-138744207 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036633
 protein coding gene ChrX:142562148-142656449 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033457
 protein coding gene ChrX:129591958-129679316 (+)
CAST/EiJ MGP_CASTEiJ_G0035108
 protein coding gene ChrX:119360809-119461593 (+)
CBA/J MGP_CBAJ_G0035794
 protein coding gene ChrX:146972429-147069782 (+)
DBA/2J MGP_DBA2J_G0035951
 protein coding gene ChrX:137030088-137125752 (+)
FVB/NJ MGP_FVBNJ_G0035885
 protein coding gene ChrX:136260503-136353771 (+)
LP/J MGP_LPJ_G0036042
 protein coding gene ChrX:139472856-139568022 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0036669
 protein coding gene ChrX:137839849-137935524 (+)
PWK/PhJ MGP_PWKPhJ_G0034801
 protein coding gene ChrX:116244550-116337630 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034627
 protein coding gene ChrX:119900660-119972021 (+)
WSB/EiJ MGP_WSBEiJ_G0035243
 protein coding gene ChrX:136155461-136194818 (+)



Homology
more
  • Human Ortholog
    ATG4A, autophagy related 4A cysteine peptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG4A, autophagy related 4A cysteine peptidase
  • Synonyms
    APG4A, AUTL2, HsAPG4A
  • Links
    NCBI Gene ID: 115201
    neXtProt AC: NX_Q8WYN0
    UniProt: Q8WYN0

  • Chr Location
    Xq22.3; chrX:108088829-108154671 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    9
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079418 Ensembl Gene Model | MGI Sequence Detail 89611 C57BL/6J ±  kb
transcript ENSMUST00000112971 Ensembl | MGI Sequence Detail 2202 Not Applicable  
polypeptide ENSMUSP00000108595 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147980
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 1
  • Earliest
    J:81439 Marino G, et al., Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem. 2003 Feb 7;278(6):3671-8
  • Latest
    J:329967 Li H, et al., Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Cell Rep. 2022 Oct 4;41(1):111435
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory