Ifit1bl2 MGI Mouse Gene Detail - MGI:2148249 - interferon induced protein with tetratricopeptide repeats 1B like 2

Symbol

Ifit1bl2
Name

interferon induced protein with tetratricopeptide repeats 1B like 2
Synonyms

2010002M12Rik

Feature Type

protein coding gene
IDs

MGI:2148249
NCBI Gene: 112419
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:34594449-34618143 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 29.76 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

363 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148249	protein coding gene	Chr19:34594446-34618163 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025063	protein coding gene	Chr19:33372732-33399934 (-)
A/J	MGP_AJ_G0025039	protein coding gene	Chr19:31749429-31784467 (-)
AKR/J	MGP_AKRJ_G0025007	protein coding gene	Chr19:32853566-32879122 (-)
BALB/cJ	MGP_BALBcJ_G0025037	protein coding gene	Chr19:31875664-31900267 (-)
C3H/HeJ	MGP_C3HHeJ_G0024796	protein coding gene	Chr19:32935045-32960695 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025478	protein coding gene	Chr19:34373288-34399214 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022893	protein coding gene	Chr19:31155356-31161963 (-)
CAST/EiJ	MGP_CASTEiJ_G0024263	protein coding gene	Chr19:32680765-32708215 (-)
CBA/J	MGP_CBAJ_G0024773	protein coding gene	Chr19:35954390-35982825 (-)
DBA/2J	MGP_DBA2J_G0024905	protein coding gene	Chr19:31658899-31683813 (-)
FVB/NJ	MGP_FVBNJ_G0024866	protein coding gene	Chr19:31485328-31509065 (-)
LP/J	MGP_LPJ_G0024991	protein coding gene	Chr19:33495637-33523940 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024896	protein coding gene	Chr19:35732528-35769039 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025536	protein coding gene	Chr19:32935785-32945019 (-)
PWK/PhJ	MGP_PWKPhJ_G0024014	protein coding gene	Chr19:31440177-31442741 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0024330	protein coding gene	Chr19:33005928-33032355 (-)

Human Ortholog

IFIT1, interferon induced protein with tetratricopeptide repeats 1

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFIT1, interferon induced protein with tetratricopeptide repeats 1
Synonyms

C56, G10P1, IFI-56, IFI56, IFI-56K, IFIT-1, IFNAI1, ISG56, P56, RNM561
Links

HGNC:5407

NCBI Gene ID: 3434

neXtProt AC: NX_P09914

UniProt: P09914
Chr Location

10q23.31; chr10:89392546-89406487 (+) GRCh38

Human Ortholog

IFIT1B, interferon induced protein with tetratricopeptide repeats 1B
Synonyms

bA149I23.6, IFIT1L
Links

HGNC:23442

NCBI Gene ID: 439996

neXtProt AC: NX_Q5T764

UniProt: Q5T764
Chr Location

10q23.31; chr10:89378056-89385205 (+) GRCh38

MGI Vertebrate Homology

Ifit1bl2 stringent orthology
2 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: IFIT1, IFIT1B
Gene Tree

Ifit1bl2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

9

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

6
UniProt

2
CCDS

CCDS29765.1

Ensembl

ENSMUSG00000067297 (Evidence)
NCBI Gene

112419

			Length	Strain/Species	Flank
genomic	ENSMUSG00000067297	Ensembl Gene Model \| MGI Sequence Detail	23695	C57BL/6J	± kb
transcript	ENSMUST00000087357	Ensembl \| MGI Sequence Detail	3367	Not Applicable
polypeptide	ENSMUSP00000093816	Ensembl \| MGI Sequence Detail	466	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat
GlyGen

Q3U687 1 site, 1 N-linked glycan (1 site)

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All nucleic 9

cDNA 9

Microarray probesets 1

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MGI:2147726

Summaries

All 26

Gene Ontology 2

Phenotypes 3
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ifit1bl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158999	Chr19:34618159-34618193 (-)	-33 bp
Tssr158998	Chr19:34618135-34618149 (-)	1 bp
Tssr158997	Chr19:34618116-34618129 (-)	20 bp
Tssr158996	Chr19:34607276-34607287 (-)	10,861 bp
Tssr158995	Chr19:34607252-34607270 (-)	10,882 bp
Tssr158994	Chr19:34607209-34607213 (-)	10,932 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24