Foxp2 MGI Mouse Gene Detail - MGI:2148705

Symbol

Foxp2
Name

forkhead box P2
Synonyms

2810043D05Rik, D0Kist7

Feature Type

protein coding gene
IDs

MGI:2148705
NCBI Gene: 114142
Alliance

gene page
Transcription Start Sites

36 TSS

Sequence Map

Chr6:14901348-15441976 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 6.49 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

14139 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148705	protein coding gene	Chr6:14901348-15441976 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030464	protein coding gene	Chr6:12029974-12603695 (+)
A/J	MGP_AJ_G0030437	protein coding gene	Chr6:11554440-12089258 (+)
AKR/J	MGP_AKRJ_G0030364	protein coding gene	Chr6:11994581-12542867 (+)
BALB/cJ	MGP_BALBcJ_G0030446	protein coding gene	Chr6:11595300-12161828 (+)
C3H/HeJ	MGP_C3HHeJ_G0030160	protein coding gene	Chr6:11866565-12429439 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030901	protein coding gene	Chr6:12452022-13023622 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028112	protein coding gene	Chr6:10651277-11171930 (+)
CAST/EiJ	MGP_CASTEiJ_G0029562	protein coding gene	Chr6:11723809-12293553 (+)
CBA/J	MGP_CBAJ_G0030138	protein coding gene	Chr6:12825639-13411784 (+)
DBA/2J	MGP_DBA2J_G0030282	protein coding gene	Chr6:11479532-12027329 (+)
FVB/NJ	MGP_FVBNJ_G0030236	protein coding gene	Chr6:11372577-11902994 (+)
LP/J	MGP_LPJ_G0030369	protein coding gene	Chr6:12110616-12666982 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030272	protein coding gene	Chr6:13720278-14436279 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030931	protein coding gene	Chr6:11859808-12420839 (+)
PWK/PhJ	MGP_PWKPhJ_G0029276	protein coding gene	Chr6:11158031-11697991 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029112	protein coding gene	Chr6:11688518-12257064 (+)
WSB/EiJ	MGP_WSBEiJ_G0029638	protein coding gene	Chr6:11783286-12344367 (+)

Human Ortholog

FOXP2, forkhead box P2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOXP2, forkhead box P2
Synonyms

CAGH44, SPCH1, TNRC10
Links

HGNC:13875

NCBI Gene ID: 93986

neXtProt AC: NX_O15409

UniProt: O15409
Chr Location

7q31.1; chr7:114086327-114693772 (+) GRCh38

MGI Vertebrate Homology

Foxp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOXP2
Gene Tree

Foxp2

Diseases

9 with human FOXP2 associations

				Human Disease	Mouse Models
				articulation disorder IDs articulation disorder DOID:4186 MESH:D001184 UMLS_CUI:C0003910
				attention deficit hyperactivity disorder IDs attention deficit hyperactivity disorder DOID:1094 DOID:1093 EFO:0003888 ICD9CM:314.8 MESH:D001289 OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312 UMLS_CUI:C0041671
				autism spectrum disorder IDs autism spectrum disorder DOID:0060041 MESH:D000067877
				autistic disorder IDs autistic disorder DOID:12849 EFO:0003758 ICD10CM:F84.0 ICD9CM:299.0 MESH:D001321 NCI:C97161 OMIM:209850 ORDO:106 UMLS_CUI:C0004352
				dyslexia IDs dyslexia DOID:4428 ICD10CM:F81.0 MESH:D004410 NCI:C96410 OMIM:300509 OMIM:600202 OMIM:604254 OMIM:606616 OMIM:606896 OMIM:608995 UMLS_CUI:C0476254
				language disorder IDs language disorder DOID:93 ICD10CM:F80.9 MESH:D007806 NCI:C97155 UMLS_CUI:C0023015
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 EFO:0003761 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C34796 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341
				speech-language disorder-1 IDs speech-language disorder-1 DOID:0111275 OMIM:602081 ORDO:209908

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

58 phenotypes from 9 alleles in 8 genetic backgrounds
16 phenotypes from multigenic genotypes
4 images
73 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (ENU)

3
Endonuclease-mediated

3
Targeted

11
Genomic Mutations

1 involving Foxp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice display postnatal lethality, growth retardation, reduced vocalization, prolonged external granule cell layer presence, abnormal Purkinje and radial glial cells, delayed eye opening and ear emergence, negative geotaxis, impaired righting response, and hypoactivity.

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All GO Annotations

50
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

2210
Tissues

390
cDNA Data

53
Literature Summary

279

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FOXP2

Xenbase foxp2

ZFIN foxp2

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All Sequences

90
RefSeq

8
UniProt

11
CCDS

CCDS19918.1, CCDS71726.1

Ensembl

ENSMUSG00000029563 (Evidence)
NCBI Gene

114142

			Length	Strain/Species	Flank
genomic	114142	NCBI Gene Model \| MGI Sequence Detail	540629	C57BL/6J	± kb
transcript	NM_053242	RefSeq \| MGI Sequence Detail	6760	C57BL/6
polypeptide	P58463	UniProt \| EBI \| MGI Sequence Detail	714	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000007644 forkhead box protein P2

(term hierarchy)
InterPro Domains

IPR050998 Forkhead box protein P

IPR047412 Forkhead box protein P1/P2, forkhead domain

IPR001766 Fork head domain

IPR030456 Fork head domain conserved site 2

IPR032354 FOXP, coiled-coil domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 72

cDNA 54

Primer pair 13

Other 5

Microarray probesets 8

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MGD-MRK-37478, MGI:108434, MGI:1919965, MGI:2141412

Summaries

All 385

Developmental Gene Expression 279

Gene Ontology 11

Phenotypes 73
Earliest

J:44212 Kim SJ, et al., Cloning of novel trinucleotide-repeat (CAG) containing genes in mouse brain. Biochem Biophys Res Commun. 1997 Nov 7;240(1):239-43
Latest

J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)

TSS for Foxp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54962	Chr6:14901211-14901225 (+)	-130 bp
Tssr54963	Chr6:14901249-14901276 (+)	-85 bp
Tssr54964	Chr6:14901286-14901341 (+)	-34 bp
Tssr54965	Chr6:14901343-14901363 (+)	5 bp
Tssr54966	Chr6:14901376-14901395 (+)	38 bp
Tssr54967	Chr6:14901402-14901421 (+)	64 bp
Tssr54968	Chr6:14901439-14901496 (+)	120 bp
Tssr54969	Chr6:14901546-14901570 (+)	210 bp
Tssr54970	Chr6:14901604-14901613 (+)	261 bp
Tssr54971	Chr6:14903483-14903503 (+)	2,145 bp
Tssr54972	Chr6:15105863-15105868 (+)	204,518 bp
Tssr54973	Chr6:15125483-15125488 (+)	224,138 bp
Tssr54974	Chr6:15184569-15184580 (+)	283,227 bp
Tssr54975	Chr6:15184630-15184661 (+)	283,298 bp
Tssr54976	Chr6:15184730-15184744 (+)	283,389 bp
Tssr54977	Chr6:15184753-15184766 (+)	283,412 bp
Tssr54978	Chr6:15185214-15185243 (+)	283,881 bp
Tssr54979	Chr6:15185369-15185392 (+)	284,033 bp
Tssr54980	Chr6:15185438-15185451 (+)	284,097 bp
Tssr54981	Chr6:15185455-15185519 (+)	284,139 bp
Tssr54982	Chr6:15185581-15185594 (+)	284,240 bp
Tssr54983	Chr6:15185606-15185625 (+)	284,268 bp
Tssr54984	Chr6:15185638-15185654 (+)	284,298 bp
Tssr54985	Chr6:15185654-15185664 (+)	284,311 bp
Tssr54986	Chr6:15185857-15185858 (+)	284,510 bp
Tssr54987	Chr6:15186803-15186843 (+)	285,475 bp
Tssr54988	Chr6:15186850-15186895 (+)	285,525 bp
Tssr54989	Chr6:15186901-15186912 (+)	285,559 bp
Tssr54990	Chr6:15197030-15197041 (+)	295,688 bp
Tssr54991	Chr6:15197061-15197073 (+)	295,719 bp
Tssr54992	Chr6:15197086-15197101 (+)	295,746 bp
Tssr54993	Chr6:15208073-15208079 (+)	306,728 bp
Tssr54994	Chr6:15326872-15326921 (+)	425,549 bp
Tssr54995	Chr6:15364485-15364494 (+)	463,142 bp
Tssr54996	Chr6:15365211-15365215 (+)	463,865 bp
Tssr54997	Chr6:15394721-15394733 (+)	493,379 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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