Tssk6 MGI Mouse Gene Detail - MGI:2148775 - testis-specific serine kinase 6

Symbol

Tssk6
Name

testis-specific serine kinase 6
Synonyms

Sstk

Feature Type

protein coding gene
IDs

MGI:2148775
NCBI Gene: 83984
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:70354834-70356168 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.05 cM, cytoband C1
Mapping Data

1 experiment

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148775	protein coding gene	Chr8:70354834-70356168 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033683	protein coding gene	Chr8:70131106-70132440 (+)
A/J	MGP_AJ_G0033666	protein coding gene	Chr8:67283548-67284882 (+)
AKR/J	MGP_AKRJ_G0033591	protein coding gene	Chr8:69189739-69191073 (+)
BALB/cJ	MGP_BALBcJ_G0033662	protein coding gene	Chr8:67509708-67511042 (+)
C3H/HeJ	MGP_C3HHeJ_G0033372	protein coding gene	Chr8:69850960-69852294 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034179	protein coding gene	Chr8:72799290-72800624 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031123	protein coding gene	Chr8:62107824-62109158 (+)
CAST/EiJ	MGP_CASTEiJ_G0032697	protein coding gene	Chr8:69315805-69317139 (+)
CBA/J	MGP_CBAJ_G0033350	protein coding gene	Chr8:75436981-75438315 (+)
DBA/2J	MGP_DBA2J_G0033504	protein coding gene	Chr8:67009941-67011275 (+)
FVB/NJ	MGP_FVBNJ_G0033445	protein coding gene	Chr8:66106592-66107926 (+)
LP/J	MGP_LPJ_G0033591	protein coding gene	Chr8:70181417-70182751 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033489	protein coding gene	Chr8:78094454-78095788 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034197	protein coding gene	Chr8:69372611-69373945 (+)
PWK/PhJ	MGP_PWKPhJ_G0032405	protein coding gene	Chr8:66294571-66295905 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032241	protein coding gene	Chr8:68349348-68350682 (+)
WSB/EiJ	MGP_WSBEiJ_G0032812	protein coding gene	Chr8:69741651-69742985 (+)

Human Ortholog

TSSK6, testis specific serine kinase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSSK6, testis specific serine kinase 6
Synonyms

CT72, FKSG82, SSTK, TSSK4
Links

HGNC:30410

NCBI Gene ID: 83983

neXtProt AC: NX_Q9BXA6

UniProt: Q9BXA6
Chr Location

19p13.11; chr19:19512418-19515548 (-) GRCh38

MGI Vertebrate Homology

Tssk6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSSK6
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Tssk6

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

1
Genomic Mutations

1 involving Tssk6
Incidental Mutations

APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile and exhibit decreased sperm numbers and sperm motility, abnormal sperm head morphology and reduced DNA compaction in spermatozoa.

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All GO Annotations

41
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS22354.1

Ensembl

ENSMUSG00000047654 (Evidence)
NCBI Gene

83984

			Length	Strain/Species	Flank
genomic	83984	NCBI Gene Model \| MGI Sequence Detail	1335	C57BL/6J	± kb
transcript	NM_032004	RefSeq \| MGI Sequence Detail	1358	C57BL/6
polypeptide	Q925K9	UniProt \| EBI \| MGI Sequence Detail	273	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016774 testis-specific serine/threonine-protein kinase 6

(term hierarchy)
PDB

8IYJ
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR042710 Testis-specific serine/threonine-protein kinase 6, catalytic domain

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All nucleic 12

cDNA 12

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 6
Earliest

J:98891 Spiridonov NA, et al., Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Mol Cell Biol. 2005 May;25(10):4250-61
Latest

J:338030 Zhou L, et al., Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell. 2023 Jun 22;186(13):2897-2910.e19

TSS for Tssk6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr2594	Chr8:70354418-70354446 (+)	-402 bp
Tssr77689	Chr8:70354828-70354844 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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