Kiss1r MGI Mouse Gene Detail - MGI:2148793

Symbol

Kiss1r
Name

KISS1 receptor
Synonyms

Gpr54

Feature Type

protein coding gene
IDs

MGI:2148793
NCBI Gene: 114229
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:79752805-79758107 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

162 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148793	protein coding gene	Chr10:79752786-79759922 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017471	protein coding gene	Chr10:80482159-80487461 (+)
A/J	MGP_AJ_G0017449	protein coding gene	Chr10:77672055-77677357 (+)
AKR/J	MGP_AKRJ_G0017410	protein coding gene	Chr10:79790539-79795842 (+)
BALB/cJ	MGP_BALBcJ_G0017411	protein coding gene	Chr10:77900661-77904429 (+)
C3H/HeJ	MGP_C3HHeJ_G0017234	protein coding gene	Chr10:79894328-79899628 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017865	protein coding gene	Chr10:83261576-83266601 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015553	protein coding gene	Chr10:73900127-73905661 (+)
CAST/EiJ	MGP_CASTEiJ_G0016801	protein coding gene	Chr10:80084145-80089278 (+)
CBA/J	MGP_CBAJ_G0017206	protein coding gene	Chr10:86485809-86489711 (+)
DBA/2J	MGP_DBA2J_G0017312	protein coding gene	Chr10:76887390-76892998 (+)
FVB/NJ	MGP_FVBNJ_G0017306	protein coding gene	Chr10:76065724-76071027 (+)
LP/J	MGP_LPJ_G0017383	protein coding gene	Chr10:80959294-80964595 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017332	protein coding gene	Chr10:88457341-88462763 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017906	protein coding gene	Chr10:79775956-79783404 (+)
PWK/PhJ	MGP_PWKPhJ_G0016582	protein coding gene	Chr10:76753244-76758617 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016371	protein coding gene	Chr10:78748647-78753941 (+)
WSB/EiJ	MGP_WSBEiJ_G0016861	protein coding gene	Chr10:79798809-79804087 (+)

Human Ortholog

KISS1R, KISS1 receptor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KISS1R, KISS1 receptor
Synonyms

AXOR12, CPPB1, GPR54, HH8, HOT7T175, KISS-1R
Links

HGNC:4510

NCBI Gene ID: 84634

neXtProt AC: NX_Q969F8

UniProt: Q969F8
Chr Location

19p13.3

MGI Vertebrate Homology

Kiss1r stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KISS1R
Gene Tree

Kiss1r

Diseases

1 with Kiss1r mouse models; 3 with human KISS1R associations

Human Disease

Mouse Models

hypogonadotropic hypogonadism 8 with or without anosmia

IDs

View 4 models

central precocious puberty 1

IDs

hypogonadism

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

4 with disease annotations

References

4 with disease annotations

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Phenotype Summary

115 phenotypes from 10 alleles in 9 genetic backgrounds
4 phenotypes from multigenic genotypes
2 images
69 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

10
Transgenic

1
Genomic Mutations

1 involving Kiss1r
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutations result in male and female infertility associated with abnormal sexual maturation and hypogonadotropic hypogonadism.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

25
cDNA Data

8
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kiss1r

ZFIN kiss1ra, kiss1rb

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All Sequences

52
RefSeq

12
UniProt

4
CCDS

CCDS23998.1

Ensembl

ENSMUSG00000035773 (Evidence)
NCBI Gene

114229

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035773	Ensembl Gene Model \| MGI Sequence Detail	5303	C57BL/6J	± kb
transcript	ENSMUST00000045529	Ensembl \| MGI Sequence Detail	3163	Not Applicable
polypeptide	ENSMUSP00000040516	Ensembl \| MGI Sequence Detail	396	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001426 KiSS-1 receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR008103 KiSS-1 peptide receptor
GlyGen

Q91V45 3 sites

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All nucleic 11

Genomic 1

cDNA 8

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 113

Developmental Gene Expression 6

Diseases 4

Gene Ontology 8

Phenotypes 69
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kiss1r:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94430	Chr10:79752791-79752820 (+)	1 bp
Tssr94431	Chr10:79754335-79754342 (+)	1,534 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24