Sec16b MGI Mouse Gene Detail - MGI:2148802 - SEC16 homolog B, endoplasmic reticulum export factor

Symbol

Sec16b
Name

SEC16 homolog B, endoplasmic reticulum export factor
Synonyms

Lztr2, Rgpr, Rgpr-p117

Feature Type

protein coding gene
IDs

MGI:2148802
NCBI Gene: 89867
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:157334303-157395995 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 68.00 cM, cytoband H1
Mapping Data

1 experiment

SNPs within 2kb

1830 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148802	protein coding gene	Chr1:157334298-157395995 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016633	protein coding gene	Chr1:162556538-162621651 (+)
A/J	MGP_AJ_G0016614	protein coding gene	Chr1:155987875-156049739 (+)
AKR/J	MGP_AKRJ_G0016580	protein coding gene	Chr1:160754461-160820529 (+)
BALB/cJ	MGP_BALBcJ_G0016575	protein coding gene	Chr1:156487409-156548975 (+)
C3H/HeJ	MGP_C3HHeJ_G0016399	protein coding gene	Chr1:160896261-160967908 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017036	protein coding gene	Chr1:168111500-168178836 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014745	protein coding gene	Chr1:148168224-148230899 (+)
CAST/EiJ	MGP_CASTEiJ_G0015979	protein coding gene	Chr1:160436129-160503310 (+)
CBA/J	MGP_CBAJ_G0016374	protein coding gene	Chr1:174067602-174143757 (+)
DBA/2J	MGP_DBA2J_G0016480	protein coding gene	Chr1:154934041-154997072 (+)
FVB/NJ	MGP_FVBNJ_G0016478	protein coding gene	Chr1:153392063-153454662 (+)
LP/J	MGP_LPJ_G0016551	protein coding gene	Chr1:163667831-163737203 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016503	protein coding gene	Chr1:181598907-181665056 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017072	protein coding gene	Chr1:160581043-160646420 (+)
PWK/PhJ	MGP_PWKPhJ_G0015765	protein coding gene	Chr1:154037753-154100829 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015552	protein coding gene	Chr1:159331392-159398625 (+)
WSB/EiJ	MGP_WSBEiJ_G0016041	protein coding gene	Chr1:160691469-160753500 (+)

Human Ortholog

CRYZL2P-SEC16B, CRYZL2P-SEC16B readthrough

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRYZL2P-SEC16B, CRYZL2P-SEC16B readthrough
Links

HGNC:53757

NCBI Gene ID: 111240474

UniProt: Q96JE7
Chr Location

chr1:177928788-178038007 (-) GRCh38

Human Ortholog

SEC16B, SEC16 homolog B, endoplasmic reticulum export factor
Synonyms

LZTR2, PGPR-p117, RGPR, RGPR-p117, SEC16S
Links

HGNC:30301

NCBI Gene ID: 89866

neXtProt AC: NX_Q96JE7

UniProt: Q96JE7
Chr Location

1q25.2; chr1:177923956-177984303 (-) GRCh38

MGI Vertebrate Homology

Sec16b stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRYZL2P-SEC16B, SEC16B
Gene Tree

Sec16b

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

2 involving Sec16b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

882
Tissues

18
cDNA Data

26
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sec16b

ZFIN sec16b

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All Sequences

54
RefSeq

15
UniProt

2
CCDS

CCDS15400.1

Ensembl

ENSMUSG00000026589 (Evidence)
NCBI Gene

89867

			Length	Strain/Species	Flank
genomic	89867	NCBI Gene Model \| MGI Sequence Detail	61693	C57BL/6J	± kb
transcript	NM_033354	RefSeq \| MGI Sequence Detail	4611	C57BL/6
polypeptide	Q91XT4	UniProt \| EBI \| MGI Sequence Detail	1051	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014582 protein transport protein Sec16B

(term hierarchy)
InterPro Domains

IPR024298 Ancestral coatomer element 1, Sec16/Sec31

IPR024880 COPII coat assembly protein, Sec16

IPR024340 Sec16, central conserved domain

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All nucleic 26

cDNA 26

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:71988 Misawa H, et al., Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int J Mol Med. 2001 Nov;8(5):513-20
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sec16b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9592	Chr1:157334327-157334346 (+)	34 bp
Tssr9593	Chr1:157334347-157334381 (+)	61 bp
Tssr260	Chr1:157353635-157353646 (+)	19,338 bp
Tssr9594	Chr1:157353648-157353662 (+)	19,352 bp
Tssr9595	Chr1:157353669-157353689 (+)	19,376 bp
Tssr9596	Chr1:157353697-157353723 (+)	19,407 bp
Tssr9597	Chr1:157353726-157353756 (+)	19,438 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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