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Dok4 Gene Detail
Summary
  • Symbol
    Dok4
  • Name
    docking protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148865
    NCBI Gene: 114255
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95590456-95602940 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.93 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148865
 protein coding gene Chr8:95590456-95602958 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033973
 protein coding gene Chr8:96306293-96317185 (-)
A/J MGP_AJ_G0033956
 protein coding gene Chr8:92552283-92564783 (-)
AKR/J MGP_AKRJ_G0033882
 protein coding gene Chr8:95075473-95087977 (-)
BALB/cJ MGP_BALBcJ_G0033948
 protein coding gene Chr8:92633755-92646297 (-)
C3H/HeJ MGP_C3HHeJ_G0033658
 protein coding gene Chr8:95787862-95801723 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034469
 protein coding gene Chr8:99816309-99828802 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031410
 protein coding gene Chr8:86354773-86367280 (-)
CAST/EiJ MGP_CASTEiJ_G0032990
 protein coding gene Chr8:95391764-95404255 (-)
CBA/J MGP_CBAJ_G0033634
 protein coding gene Chr8:103110571-103123112 (-)
DBA/2J MGP_DBA2J_G0033788
 protein coding gene Chr8:92031670-92044588 (-)
FVB/NJ MGP_FVBNJ_G0033735
 protein coding gene Chr8:90982241-90994712 (-)
LP/J MGP_LPJ_G0033880
 protein coding gene Chr8:96451220-96462573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033777
 protein coding gene Chr8:105399610-105412101 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034487
 protein coding gene Chr8:95239814-95253668 (-)
PWK/PhJ MGP_PWKPhJ_G0032692
 protein coding gene Chr8:91399379-91411869 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032529
 protein coding gene Chr8:94084084-94096553 (-)
WSB/EiJ MGP_WSBEiJ_G0033102
 protein coding gene Chr8:95774677-95787169 (-)



Homology
more
  • Human Ortholog
    DOK4, docking protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOK4, docking protein 4
  • Synonyms
    IRS-5, IRS5
  • Links
    NCBI Gene ID: 55715
    neXtProt AC: NX_Q8TEW6
    UniProt: Q8TEW6

  • Chr Location
    16q21; chr16:57471922-57487327 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    45
  • cDNA Data
    68
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 114255 NCBI Gene Model | MGI Sequence Detail 12485 C57BL/6J ±  kb
transcript NM_053246 RefSeq | MGI Sequence Detail 2604 C57BL/6  
polypeptide Q99KE3 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    cDNA 70
    Primer pair 3

    Microarray probesets 6
References
more
  • Summaries
    All 31
    Developmental Gene Expression 7
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:70544 Grimm J, et al., Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001 Jul 23;154(2):345-54
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory