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Clic1 Gene Detail
Summary
  • Symbol
    Clic1
  • Name
    chloride intracellular channel 1
  • Synonyms
    Clcp, G6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148924
    NCBI Gene: 114584
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35269219-35277695 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148924
 protein coding gene Chr17:35268942-35277725 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023609
 protein coding gene Chr17:35186313-35198553 (+)
A/J MGP_AJ_G0023569
 protein coding gene Chr17:34023991-34032524 (+)
AKR/J MGP_AKRJ_G0023537
 protein coding gene Chr17:34494980-34507109 (+)
BALB/cJ MGP_BALBcJ_G0023575
 protein coding gene Chr17:34155391-34168841 (+)
C3H/HeJ MGP_C3HHeJ_G0023336
 protein coding gene Chr17:34890506-34899911 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024014
 protein coding gene Chr17:36527314-36535511 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021495
 protein coding gene Chr17:31790594-31799680 (+)
CAST/EiJ MGP_CASTEiJ_G0022833
 protein coding gene Chr17:34893888-34902547 (+)
CBA/J MGP_CBAJ_G0023314
 protein coding gene Chr17:38033902-38042546 (+)
DBA/2J MGP_DBA2J_G0023442
 protein coding gene Chr17:33344238-33352817 (+)
FVB/NJ MGP_FVBNJ_G0023409
 protein coding gene Chr17:33180775-33189334 (+)
LP/J MGP_LPJ_G0023519
 protein coding gene Chr17:35512747-35524236 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023431
 protein coding gene Chr17:36968200-36978235 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024059
 protein coding gene Chr17:34717640-34726310 (+)
PWK/PhJ MGP_PWKPhJ_G0022580
 protein coding gene Chr17:32177144-32186230 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022400
 protein coding gene Chr17:32728139-32736519 (+)
WSB/EiJ MGP_WSBEiJ_G0022896
 protein coding gene Chr17:34834429-34845332 (+)



Homology
more
  • Human Ortholog
    CLIC1, chloride intracellular channel 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLIC1, chloride intracellular channel 1
  • Synonyms
    CL1C1, CLCNL1, G6, NCC27
  • Links
    NCBI Gene ID: 1192
    neXtProt AC: NX_O00299
    UniProt: O00299

  • Chr Location
    6p21.33; chr6:31730581-31739763 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormal platelet number, activation and aggregation and prolonged bleeding time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    12
  • cDNA Data
    268
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 114584 NCBI Gene Model | MGI Sequence Detail 8477 C57BL/6J ±  kb
transcript NM_033444 RefSeq | MGI Sequence Detail 1159 C57BL/6  
polypeptide Q9Z1Q5 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005574 chloride intracellular channel protein 1
    (term hierarchy)
  • EC
    1.8.-.-, 1.8.5.1
  • InterPro Domains
    IPR030259 Chloride intracellular channel protein 1, C-terminal domain
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR040079 Glutathione transferase family
    IPR002946 Intracellular chloride channel
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    Q9Z1Q5 3 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 272
    Genomic 1
    cDNA 268
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
  • Latest
    J:358253 Ko M, et al., Inhibition of chloride intracellular channel protein 1 (CLIC1) ameliorates liver fibrosis phenotype by activating the Ca(2+)-dependent Nrf2 pathway. Biomed Pharmacother. 2023 Dec;168:115776
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory