Ly6g6d MGI Mouse Gene Detail - MGI:2148931 - lymphocyte antigen 6 family member G6D

Symbol

Ly6g6d
Name

lymphocyte antigen 6 family member G6D
Synonyms

A930024F17Rik, G6d, G6f, MEGT1, NG25, NG32

Feature Type

protein coding gene
IDs

MGI:2148931
NCBI Gene: 114654
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:35290419-35297041 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.59 cM
Mapping Data

1 experiment

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2148931	protein coding gene	Chr17:35290318-35300215 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023613	protein coding gene	Chr17:35212759-35219381 (-)
A/J	MGP_AJ_G0023573	protein coding gene	Chr17:34045144-34051810 (-)
AKR/J	MGP_AKRJ_G0023541	protein coding gene	Chr17:34519723-34526382 (-)
BALB/cJ	MGP_BALBcJ_G0023579	protein coding gene	Chr17:34181818-34188560 (-)
C3H/HeJ	MGP_C3HHeJ_G0023340	protein coding gene	Chr17:34912516-34919227 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024018	protein coding gene	Chr17:36548191-36554813 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021499	protein coding gene	Chr17:31812091-31819617 (-)
CAST/EiJ	MGP_CASTEiJ_G0022837	protein coding gene	Chr17:34915190-34921756 (-)
CBA/J	MGP_CBAJ_G0023318	protein coding gene	Chr17:38055278-38061897 (-)
DBA/2J	MGP_DBA2J_G0023446	protein coding gene	Chr17:33366040-33372706 (-)
FVB/NJ	MGP_FVBNJ_G0023413	protein coding gene	Chr17:33203471-33210111 (-)
LP/J	MGP_LPJ_G0023523	protein coding gene	Chr17:35536946-35543568 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023435	protein coding gene	Chr17:36992572-37000319 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024063	protein coding gene	Chr17:34738953-34745577 (-)
PWK/PhJ	MGP_PWKPhJ_G0022584	protein coding gene	Chr17:32199013-32205671 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022404	protein coding gene	Chr17:32749223-32755958 (-)
WSB/EiJ	MGP_WSBEiJ_G0022900	protein coding gene	Chr17:34858032-34864653 (-)

Human Ortholog

LY6G6D, lymphocyte antigen 6 family member G6D

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LY6G6D, lymphocyte antigen 6 family member G6D
Synonyms

C6orf23, G6D, LY6-D, MEGT1, NG25
Links

HGNC:13935

NCBI Gene ID: 58530

neXtProt AC: NX_O95868

UniProt: O95868
Chr Location

6p21.33; chr6:31715348-31717919 (+) GRCh38

MGI Vertebrate Homology

Ly6g6d stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LY6G6D
Gene Tree

Ly6g6d

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Gene trapped

22
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

7
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

52
RefSeq

10
UniProt

3
CCDS

CCDS28678.1

Ensembl

ENSMUSG00000073413 (Evidence)
NCBI Gene

114654

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073413	Ensembl Gene Model \| MGI Sequence Detail	6623	C57BL/6J	± kb
transcript	ENSMUST00000007259	Ensembl \| MGI Sequence Detail	546	Not Applicable
polypeptide	ENSMUSP00000007259	Ensembl \| MGI Sequence Detail	135	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009993 lymphocyte antigen 6 complex locus protein G6d

(term hierarchy)
InterPro Domains

IPR026524 Lymphocyte antigen 6 complex locus protein G6d/G6f

IPR045860 Snake toxin-like superfamily
GlyGen

Q9Z1Q3 1 site

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All nucleic 13

Genomic 1

cDNA 9

Primer pair 2

Other 1

Microarray probesets 2

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MGI:2442450

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 9
Earliest

J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ly6g6d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147742	Chr17:35293461-35293473 (-)	3,574 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24