Unc13c MGI Mouse Gene Detail - MGI:2149021

Symbol

Unc13c
Name

unc-13 homolog C
Synonyms

1500037O19Rik, D9Ertd414e, MGC:40770, Munc13-3, Unc13h3

Feature Type

protein coding gene
IDs

MGI:2149021
NCBI Gene: 208898
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:73386704-73876248 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 40.80 cM
Mapping Data

4 experiments

SNPs within 2kb

14012 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2149021	protein coding gene	Chr9:73386704-73915421 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035029	protein coding gene	Chr9:73710809-74213491 (-)
A/J	MGP_AJ_G0035010	protein coding gene	Chr9:71145517-71624167 (-)
AKR/J	MGP_AKRJ_G0034939	protein coding gene	Chr9:72835160-73334361 (-)
BALB/cJ	MGP_BALBcJ_G0035002	protein coding gene	Chr9:70830096-71304288 (-)
C3H/HeJ	MGP_C3HHeJ_G0034711	protein coding gene	Chr9:73322734-73803287 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035521	protein coding gene	Chr9:75636903-76171243 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032432	protein coding gene	Chr9:70565916-71028913 (-)
CAST/EiJ	MGP_CASTEiJ_G0034033	protein coding gene	Chr9:73647017-74137480 (-)
CBA/J	MGP_CBAJ_G0034684	protein coding gene	Chr9:78260299-78793896 (-)
DBA/2J	MGP_DBA2J_G0034843	protein coding gene	Chr9:70830803-71307090 (-)
FVB/NJ	MGP_FVBNJ_G0034785	protein coding gene	Chr9:70154628-70629755 (-)
LP/J	MGP_LPJ_G0034924	protein coding gene	Chr9:73939429-74446869 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034826	protein coding gene	Chr9:79372609-79931893 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035543	protein coding gene	Chr9:72988405-73491638 (-)
PWK/PhJ	MGP_PWKPhJ_G0033737	protein coding gene	Chr9:71108900-71590191 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033570	protein coding gene	Chr9:73248324-73738294 (-)
WSB/EiJ	MGP_WSBEiJ_G0034145	protein coding gene	Chr9:72898517-73409104 (-)

Human Ortholog

UNC13C, unc-13 homolog C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UNC13C, unc-13 homolog C
Links

HGNC:23149

NCBI Gene ID: 440279

neXtProt AC: NX_Q8NB66

UniProt: Q8NB66
Chr Location

15q21.3; chr15:53837602-54633440 (+) GRCh38

MGI Vertebrate Homology

Unc13c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UNC13C
Gene Tree

Unc13c

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

2
Genomic Mutations

1 involving Unc13c
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

118 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice demonstrate an impaired ability to learn complex motor tasks, putatively due to an observed increase in paired-pulse facilitation.

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

23
cDNA Data

37
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA UNC13C

Xenbase unc13c

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All Sequences

48
RefSeq

12
UniProt

2
CCDS

CCDS40690.1

Ensembl

ENSMUSG00000062151 (Evidence)
NCBI Gene

208898

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062151	Ensembl Gene Model \| MGI Sequence Detail	489545	C57BL/6J	± kb
transcript	ENSMUST00000075245	Ensembl \| MGI Sequence Detail	6633	Not Applicable
polypeptide	ENSMUSP00000074726	Ensembl \| MGI Sequence Detail	2210	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017088 protein unc-13 homolog C

(term hierarchy)
InterPro Domains

IPR046349 C1-like domain superfamily

IPR000008 C2 domain

IPR035892 C2 domain superfamily

IPR014772 Mammalian uncoordinated homology 13, domain 2

IPR014770 Munc13 homology 1

IPR010439 MUN domain

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR027080 Protein Unc-13

IPR037302 Protein Unc-13, C2B domain
GlyGen

Q8K0T7 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 39

cDNA 37

Primer pair 2

Microarray probesets 11

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MGI:1196392, MGI:1917504, MGI:2143201

Summaries

All 56

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 19
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Unc13c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90516	Chr9:73876381-73876391 (-)	-138 bp
Tssr90515	Chr9:73876340-73876354 (-)	-99 bp
Tssr90514	Chr9:73876313-73876327 (-)	-72 bp
Tssr90513	Chr9:73876183-73876281 (-)	16 bp
Tssr90512	Chr9:73875952-73875991 (-)	276 bp
Tssr90511	Chr9:73875093-73875104 (-)	1,149 bp
Tssr90510	Chr9:73738564-73738569 (-)	137,681 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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