About   Help   FAQ
Otoa Gene Detail
Summary
  • Symbol
    Otoa
  • Name
    otoancorin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149209
    NCBI Gene: 246190
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:120682647-120762316 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 65.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2352 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149209
 protein coding gene Chr7:120680873-120762320 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032941
 protein coding gene Chr7:125103974-125188118 (+)
A/J MGP_AJ_G0032924
 protein coding gene Chr7:121839117-121926758 (+)
AKR/J MGP_AKRJ_G0032856
 protein coding gene Chr7:124963381-125046211 (+)
BALB/cJ MGP_BALBcJ_G0032929
 protein coding gene Chr7:121556715-121639222 (+)
C3H/HeJ MGP_C3HHeJ_G0032639
 protein coding gene Chr7:124880641-124962647 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033435
 protein coding gene Chr7:130050112-130132398 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030407
 protein coding gene Chr7:123210337-123288450 (+)
CAST/EiJ MGP_CASTEiJ_G0031967
 protein coding gene Chr7:116645624-116735195 (+)
CBA/J MGP_CBAJ_G0032612
 protein coding gene Chr7:134383088-134477567 (+)
DBA/2J MGP_DBA2J_G0032764
 protein coding gene Chr7:119873821-119954204 (+)
FVB/NJ MGP_FVBNJ_G0032717
 protein coding gene Chr7:119731266-119809221 (+)
LP/J MGP_LPJ_G0032858
 protein coding gene Chr7:126546465-126629677 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032749
 protein coding gene Chr7:135845012-135940997 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033455
 protein coding gene Chr7:123957678-124041231 (+)
PWK/PhJ MGP_PWKPhJ_G0031675
 protein coding gene Chr7:112801668-112882851 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031521
 protein coding gene Chr7:110717853-110807300 (+)
WSB/EiJ MGP_WSBEiJ_G0032080
 protein coding gene Chr7:124882804-124965790 (+)



Homology
more
  • Human Ortholog
    OTOA, otoancorin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTOA, otoancorin
  • Synonyms
    CT108, DFNB22
  • Links
    NCBI Gene ID: 146183
    neXtProt AC: NX_Q7RTW8
    UniProt: Q7RTW8

  • Chr Location
    16p12.2; chr16:21663968-21761935 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Otoa mouse models; 1 with human OTOA associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hearing loss, detachment of the tectorial membrane from the spiral limbus, abnormal tectorial membrane morphology, absence of Hensen's stripe and increased cochlear nerve coumpond action potential threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    24
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 246190 NCBI Gene Model | MGI Sequence Detail 79670 C57BL/6J ±  kb
    transcript NM_139310 RefSeq | MGI Sequence Detail 3663 C57BL/6  
    polypeptide Q8K561 UniProt | EBI | MGI Sequence Detail 1137 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:76334 Zwaenepoel I, et al., Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6240-5
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory