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Greb1 Gene Detail
Summary
  • Symbol
    Greb1
  • Name
    gene regulated by estrogen in breast cancer protein
  • Synonyms
    5730583K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149712
    NCBI Gene: 268527
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:16720616-16850887 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 8.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4048 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149712
 protein coding gene Chr12:16720616-16851395 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019611
 protein coding gene Chr12:14062033-14200102 (-)
A/J MGP_AJ_G0019578
 protein coding gene Chr12:13572027-13705130 (-)
AKR/J MGP_AKRJ_G0019548
 protein coding gene Chr12:14221342-14355715 (-)
BALB/cJ MGP_BALBcJ_G0019554
 protein coding gene Chr12:13815531-13949285 (-)
C3H/HeJ MGP_C3HHeJ_G0019359
 protein coding gene Chr12:14124504-14264474 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020002
 protein coding gene Chr12:14525589-14670181 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017628
 protein coding gene Chr12:13069446-13202201 (-)
CAST/EiJ MGP_CASTEiJ_G0018914
 protein coding gene Chr12:14004094-14144724 (-)
CBA/J MGP_CBAJ_G0019330
 protein coding gene Chr12:15322119-15480040 (-)
DBA/2J MGP_DBA2J_G0019443
 protein coding gene Chr12:13489040-13621850 (-)
FVB/NJ MGP_FVBNJ_G0019434
 protein coding gene Chr12:13373722-13507870 (-)
LP/J MGP_LPJ_G0019514
 protein coding gene Chr12:14181667-14322029 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019469
 protein coding gene Chr12:15227514-15368082 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020041
 protein coding gene Chr12:13905950-14043835 (-)
PWK/PhJ MGP_PWKPhJ_G0018680
 protein coding gene Chr12:13521239-13656901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018470
 protein coding gene Chr12:14120174-14253690 (-)
WSB/EiJ MGP_WSBEiJ_G0018965
 protein coding gene Chr12:14017626-14160084 (-)



Homology
more
  • Human Ortholog
    GREB1, growth regulating estrogen receptor binding 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GREB1, growth regulating estrogen receptor binding 1
  • Links
    NCBI Gene ID: 9687
    neXtProt AC: NX_Q4ZG55
    UniProt: Q4ZG55

  • Chr Location
    2p25.1; chr2:11482341-11642788 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females are subfertile with decreased litter sizes, have impaired embryo implantation and uterine receptivity due to impaired uterine responses to steroid hormones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    867
  • Tissues
    90
  • cDNA Data
    17
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036523 Ensembl Gene Model | MGI Sequence Detail 130272 C57BL/6J ±  kb
    transcript ENSMUST00000048064 Ensembl | MGI Sequence Detail 7940 Not Applicable  
    polypeptide ENSMUSP00000044454 Ensembl | MGI Sequence Detail 1954 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1354180, MGI:2144961
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 10
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:60252 Peterfy M, et al., Genetic, physical, and transcript map of the fld region on mouse chromosome 12. Genomics. 1999 Dec 15;62(3):436-44
    • Latest
      J:346713 Chadchan SB, et al., A GREB1-steroid receptor feedforward mechanism governs differential GREB1 action in endometrial function and endometriosis. Nat Commun. 2024 Mar 2;15(1):1947
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory