Mta1 MGI Mouse Gene Detail - MGI:2150037

Symbol

Mta1
Name

metastasis associated 1

Feature Type

protein coding gene
IDs

MGI:2150037
NCBI Gene: 116870
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr12:113061898-113100826 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.57 cM, cytoband F
Mapping Data

3 experiments

SNPs within 2kb

190 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150037	protein coding gene	Chr12:113061830-113100826 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020171	protein coding gene	Chr12:115592924-115633257 (+)
A/J	MGP_AJ_G0020127	protein coding gene	Chr12:111116819-111155407 (+)
AKR/J	MGP_AKRJ_G0020102	protein coding gene	Chr12:114347997-114386620 (+)
BALB/cJ	MGP_BALBcJ_G0020112	protein coding gene	Chr12:111559300-111620922 (+)
C3H/HeJ	MGP_C3HHeJ_G0019914	protein coding gene	Chr12:114871128-114908564 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020557	protein coding gene	Chr12:119141486-119178646 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018171	protein coding gene	Chr12:107551065-107588742 (+)
CAST/EiJ	MGP_CASTEiJ_G0019454	protein coding gene	Chr12:109706751-109752926 (+)
CBA/J	MGP_CBAJ_G0019881	protein coding gene	Chr12:123678289-123746637 (+)
DBA/2J	MGP_DBA2J_G0019998	protein coding gene	Chr12:110617749-110656527 (+)
FVB/NJ	MGP_FVBNJ_G0019983	protein coding gene	Chr12:109433009-109500144 (+)
LP/J	MGP_LPJ_G0020072	protein coding gene	Chr12:115412140-115453591 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020021	protein coding gene	Chr12:126792111-126833202 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020586	protein coding gene	Chr12:113862929-113903323 (+)
PWK/PhJ	MGP_PWKPhJ_G0019216	protein coding gene	Chr12:105252006-105318235 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019020	protein coding gene	Chr12:108016675-108083314 (+)
WSB/EiJ	MGP_WSBEiJ_G0019514	protein coding gene	Chr12:114777364-114817565 (+)

Human Ortholog

MTA1, metastasis associated 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTA1, metastasis associated 1
Links

HGNC:7410

NCBI Gene ID: 9112

neXtProt AC: NX_Q13330

UniProt: Q13330
Chr Location

14q32.33; chr14:105419820-105470729 (+) GRCh38

MGI Vertebrate Homology

Mta1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTA1
Gene Tree

Mta1

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Phenotype Summary

16 phenotypes from 3 alleles in 5 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Endonuclease-mediated

3
Gene trapped

25
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to ionizing radiation and increased retinal cell proliferation at E14.5.

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All GO Annotations

74
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

81
cDNA Data

101
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MTA1

Xenbase mta1

ZFIN mta1

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All Sequences

101
RefSeq

34
UniProt

12
CCDS

CCDS36574.1, CCDS84004.1

Ensembl

ENSMUSG00000021144 (Evidence)
NCBI Gene

116870

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021144	Ensembl Gene Model \| MGI Sequence Detail	38929	C57BL/6J	± kb
transcript	ENSMUST00000009099	Ensembl \| MGI Sequence Detail	2826	Not Applicable
polypeptide	ENSMUSP00000009099	Ensembl \| MGI Sequence Detail	715	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000010707 metastasis-associated protein MTA1

(term hierarchy)
InterPro Domains

IPR001025 Bromo adjacent homology (BAH) domain

IPR043151 Bromo adjacent homology (BAH) domain superfamily

IPR000949 ELM2 domain

IPR009057 Homeobox-like domain superfamily

IPR040138 Mesoderm induction early response protein/metastasis-associated protein

IPR035170 Metastasis-associated protein MTA1, R1 domain

IPR017884 SANT domain

IPR001005 SANT/Myb domain

IPR000679 Zinc finger, GATA-type

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All nucleic 107

Genomic 1

cDNA 101

Primer pair 4

Other 1

Microarray probesets 3

Summaries

All 84

Developmental Gene Expression 13

Gene Ontology 24

Phenotypes 27
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mta1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115471	Chr12:113061819-113061887 (+)	-45 bp
Tssr115472	Chr12:113096449-113096472 (+)	34,563 bp
Tssr115473	Chr12:113096796-113096835 (+)	34,918 bp
Tssr115474	Chr12:113097089-113097100 (+)	35,197 bp
Tssr115475	Chr12:113097128-113097148 (+)	35,240 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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