Slc4a10 MGI Mouse Gene Detail - MGI:2150150 - solute carrier family 4, sodium bicarbonate cotransporter-like, member 10

Symbol

Slc4a10
Name

solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms

NCBE

Feature Type

protein coding gene
IDs

MGI:2150150
NCBI Gene: 94229
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:61876806-62157074 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 35.79 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

6804 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150150	protein coding gene	Chr2:61876806-62157087 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025768	protein coding gene	Chr2:61707227-62007217 (+)
A/J	MGP_AJ_G0025744	protein coding gene	Chr2:59358269-59633717 (+)
AKR/J	MGP_AKRJ_G0025714	protein coding gene	Chr2:60956712-61231856 (+)
BALB/cJ	MGP_BALBcJ_G0025739	protein coding gene	Chr2:59456544-59734573 (+)
C3H/HeJ	MGP_C3HHeJ_G0025500	protein coding gene	Chr2:61058312-61338209 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026186	protein coding gene	Chr2:63544864-63830185 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023590	protein coding gene	Chr2:57053791-57154221 (+)
CAST/EiJ	MGP_CASTEiJ_G0024964	protein coding gene	Chr2:61113077-61405771 (+)
CBA/J	MGP_CBAJ_G0025480	protein coding gene	Chr2:65931683-66245882 (+)
DBA/2J	MGP_DBA2J_G0025611	protein coding gene	Chr2:58936184-59213893 (+)
FVB/NJ	MGP_FVBNJ_G0025573	protein coding gene	Chr2:58463307-58734336 (+)
LP/J	MGP_LPJ_G0025699	protein coding gene	Chr2:61552710-61836929 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025604	protein coding gene	Chr2:67567434-67939893 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026243	protein coding gene	Chr2:61004234-61299686 (+)
PWK/PhJ	MGP_PWKPhJ_G0024705	protein coding gene	Chr2:58798405-59077618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024512	protein coding gene	Chr2:61118713-61399077 (+)
WSB/EiJ	MGP_WSBEiJ_G0025032	protein coding gene	Chr2:61336319-61614208 (+)

Human Ortholog

SLC4A10, solute carrier family 4 member 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC4A10, solute carrier family 4 member 10
Synonyms

NBCn2, NCBE
Links

HGNC:13811

NCBI Gene ID: 57282

neXtProt AC: NX_Q6U841

UniProt: Q6U841
Chr Location

2q24.2; chr2:161424332-161985282 (+) GRCh38

MGI Vertebrate Homology

Slc4a10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SLC4A10
Gene Tree

Slc4a10

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Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Slc4a10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.

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All GO Annotations

46
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1026
Tissues

205
cDNA Data

32
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc4a10

ZFIN slc4a10a, slc4a10b

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All Sequences

97
RefSeq

40
UniProt

5
CCDS

CCDS16064.1, CCDS57172.1, CCDS57173.1

Ensembl

ENSMUSG00000026904 (Evidence)
NCBI Gene

94229

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026904	Ensembl Gene Model \| MGI Sequence Detail	280269	C57BL/6J	± kb
transcript	ENSMUST00000112480	Ensembl \| MGI Sequence Detail	5389	Not Applicable
polypeptide	ENSMUSP00000108099	Ensembl \| MGI Sequence Detail	1118	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015155 sodium-driven chloride bicarbonate exchanger

(term hierarchy)
InterPro Domains

IPR013769 Band 3 cytoplasmic domain

IPR003020 Bicarbonate transporter, eukaryotic

IPR011531 Bicarbonate transporter-like, transmembrane domain

IPR016152 Phosphotransferase/anion transporter

IPR003024 Sodium bicarbonate cotransporter
GlyGen

Q5DTL9 4 sites, 3 N-linked glycans (3 sites)

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All nucleic 36

cDNA 33

Primer pair 3

Microarray probesets 4

Summaries

All 63

Developmental Gene Expression 13

Gene Ontology 18

Phenotypes 21
Earliest

J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc4a10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17948	Chr2:61876835-61876849 (+)	36 bp
Tssr17949	Chr2:61876855-61876915 (+)	79 bp
Tssr17950	Chr2:61876924-61876937 (+)	125 bp
Tssr506	Chr2:61876942-61876955 (+)	143 bp
Tssr17951	Chr2:61876958-61876965 (+)	156 bp
Tssr17952	Chr2:61876967-61876978 (+)	167 bp
Tssr17953	Chr2:61978115-61978130 (+)	101,317 bp
Tssr17954	Chr2:61978146-61978170 (+)	101,352 bp
Tssr17955	Chr2:61978172-61978217 (+)	101,389 bp
Tssr17956	Chr2:61978317-61978320 (+)	101,513 bp
Tssr17957	Chr2:62156281-62156283 (+)	279,476 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24