Ubqln4 MGI Mouse Gene Detail - MGI:2150152

Symbol

Ubqln4
Name

ubiquilin 4
Synonyms

UBIN

Feature Type

protein coding gene
IDs

MGI:2150152
NCBI Gene: 94232
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:88461065-88477032 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.87 cM
Mapping Data

2 experiments

SNPs within 2kb

372 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150152	protein coding gene	Chr3:88460984-88477032 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027402	protein coding gene	Chr3:88723165-88739149 (+)
A/J	MGP_AJ_G0027366	protein coding gene	Chr3:85729238-85745843 (+)
AKR/J	MGP_AKRJ_G0027330	protein coding gene	Chr3:87843554-87859882 (+)
BALB/cJ	MGP_BALBcJ_G0027375	protein coding gene	Chr3:85814860-85830942 (+)
C3H/HeJ	MGP_C3HHeJ_G0027117	protein coding gene	Chr3:88100741-88116901 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027821	protein coding gene	Chr3:92023330-92041009 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025173	protein coding gene	Chr3:81329739-81345890 (+)
CAST/EiJ	MGP_CASTEiJ_G0026563	protein coding gene	Chr3:88344128-88361956 (+)
CBA/J	MGP_CBAJ_G0027091	protein coding gene	Chr3:95193130-95209293 (+)
DBA/2J	MGP_DBA2J_G0027229	protein coding gene	Chr3:85213395-85229477 (+)
FVB/NJ	MGP_FVBNJ_G0027197	protein coding gene	Chr3:83483002-83499277 (+)
LP/J	MGP_LPJ_G0027338	protein coding gene	Chr3:89733203-89750650 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027217	protein coding gene	Chr3:101401205-101418974 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027880	protein coding gene	Chr3:87590618-87606593 (+)
PWK/PhJ	MGP_PWKPhJ_G0026297	protein coding gene	Chr3:84991777-85008065 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026116	protein coding gene	Chr3:86776138-86793246 (+)
WSB/EiJ	MGP_WSBEiJ_G0026645	protein coding gene	Chr3:87945195-87962102 (+)

Human Ortholog

UBQLN4, ubiquilin 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBQLN4, ubiquilin 4
Synonyms

A1U, A1Up, C1orf6, CIP75, UBIN
Links

HGNC:1237

NCBI Gene ID: 56893

neXtProt AC: NX_Q9NRR5

UniProt: Q9NRR5
Chr Location

1q22; chr1:156031247-156053798 (-) GRCh38

MGI Vertebrate Homology

Ubqln4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBQLN4
Gene Tree

Ubqln4

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References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

36
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Ubqln4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

39
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

8
cDNA Data

126
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ubqln4

ZFIN ubqln4

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All Sequences

66
RefSeq

11
UniProt

2
CCDS

CCDS17479.1

Ensembl

ENSMUSG00000008604 (Evidence)
NCBI Gene

94232

			Length	Strain/Species	Flank
genomic	ENSMUSG00000008604	Ensembl Gene Model \| MGI Sequence Detail	15968	C57BL/6J	± kb
transcript	ENSMUST00000008748	Ensembl \| MGI Sequence Detail	3330	Not Applicable
polypeptide	ENSMUSP00000008748	Ensembl \| MGI Sequence Detail	596	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017010 ubiquilin-4

(term hierarchy)
PDB

2KNZ
InterPro Domains

IPR006636 Heat shock chaperonin-binding

IPR009060 UBA-like superfamily

IPR015496 Ubiquilin

IPR015940 Ubiquitin-associated domain

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q99NB8 1 site, 1 O-linked glycan (1 site)

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All nucleic 126

cDNA 126

Microarray probesets 6

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MGI:2139784

Summaries

All 45

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 17
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ubqln4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr934	Chr3:88461014-88461043 (+)	-36 bp
Tssr29961	Chr3:88461061-88461113 (+)	22 bp
Tssr29962	Chr3:88470491-88470528 (+)	9,445 bp
Tssr935	Chr3:88471070-88471108 (+)	10,024 bp
Tssr29963	Chr3:88471754-88471766 (+)	10,695 bp
Tssr29964	Chr3:88475545-88475572 (+)	14,494 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24