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Plcz1 Gene Detail
Summary
  • Symbol
    Plcz1
  • Name
    phospholipase C, zeta 1
  • Synonyms
    1700041H07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150308
    NCBI Gene: 114875
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:139935399-139987183 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 69.77 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1745 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150308
 protein coding gene Chr6:139933118-139987188 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031446
 protein coding gene Chr6:144659729-144713284 (-)
A/J MGP_AJ_G0031421
 protein coding gene Chr6:138911937-138963525 (-)
AKR/J MGP_AKRJ_G0031349
 protein coding gene Chr6:143086165-143137953 (-)
BALB/cJ MGP_BALBcJ_G0031428
 protein coding gene Chr6:138765244-138819214 (-)
C3H/HeJ MGP_C3HHeJ_G0031150
 protein coding gene Chr6:143163909-143217937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031890
 protein coding gene Chr6:148599070-148651191 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029019
 protein coding gene Chr6:137843708-137896988 (-)
CAST/EiJ MGP_CASTEiJ_G0030518
 protein coding gene Chr6:142719575-142772655 (-)
CBA/J MGP_CBAJ_G0031110
 protein coding gene Chr6:154237722-154295957 (-)
DBA/2J MGP_DBA2J_G0031267
 protein coding gene Chr6:137788798-137841621 (-)
FVB/NJ MGP_FVBNJ_G0031218
 protein coding gene Chr6:136579801-136631589 (-)
LP/J MGP_LPJ_G0031351
 protein coding gene Chr6:144775722-144834696 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031258
 protein coding gene Chr6:158162048-158215763 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031922
 protein coding gene Chr6:142902959-142957655 (-)
PWK/PhJ MGP_PWKPhJ_G0030245
 protein coding gene Chr6:136278171-136331153 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030069
 protein coding gene Chr6:141138163-141200038 (-)
WSB/EiJ MGP_WSBEiJ_G0030611
 protein coding gene Chr6:143551435-143610279 (-)



Homology
more
  • Human Ortholog
    PLCZ1, phospholipase C zeta 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCZ1, phospholipase C zeta 1
  • Synonyms
    NYD-SP27, PLCzeta, PLC-zeta-1, SPGF17
  • Links
    NCBI Gene ID: 89869
    neXtProt AC: NX_Q86YW0
    UniProt: Q86YW0

  • Chr Location
    12p12.3; chr12:18645609-18738100 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLCZ1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice display normal spermatogenesis and sperm motility but are sub-fertile because of a failure to induce Ca2+ oscillations in oocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    94
  • cDNA Data
    8
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030230 Ensembl Gene Model | MGI Sequence Detail 51785 C57BL/6J ±  kb
    transcript ENSMUST00000032356 Ensembl | MGI Sequence Detail 2271 Not Applicable  
    polypeptide ENSMUSP00000032356 Ensembl | MGI Sequence Detail 647 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000012842 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
      (term hierarchy)
    • EC
      3.1.4.11
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:77754 Saunders CM, et al., PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development. 2002 Aug;129(15):3533-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory