Dscaml1 MGI Mouse Gene Detail - MGI:2150309 - DS cell adhesion molecule like 1

Symbol

Dscaml1
Name

DS cell adhesion molecule like 1
Synonyms

4921507G06Rik, 4930435C18Rik, mKIAA1132

Feature Type

protein coding gene
IDs

MGI:2150309
NCBI Gene: 114873
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr9:45338735-45665011 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

9030 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150309	protein coding gene	Chr9:45337926-45665011 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034739	protein coding gene	Chr9:43990838-44334775 (+)
A/J	MGP_AJ_G0034720	protein coding gene	Chr9:42764821-43095246 (+)
AKR/J	MGP_AKRJ_G0034647	protein coding gene	Chr9:43640911-43975332 (+)
BALB/cJ	MGP_BALBcJ_G0034711	protein coding gene	Chr9:42491144-42818538 (+)
C3H/HeJ	MGP_C3HHeJ_G0034422	protein coding gene	Chr9:44097254-44433259 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035232	protein coding gene	Chr9:45276974-45623008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032146	protein coding gene	Chr9:42309674-42633373 (+)
CAST/EiJ	MGP_CASTEiJ_G0033744	protein coding gene	Chr9:43957678-44295708 (+)
CBA/J	MGP_CBAJ_G0034394	protein coding gene	Chr9:46936274-47293696 (+)
DBA/2J	MGP_DBA2J_G0034553	protein coding gene	Chr9:42645879-42970733 (+)
FVB/NJ	MGP_FVBNJ_G0034494	protein coding gene	Chr9:41908563-42236715 (+)
LP/J	MGP_LPJ_G0034634	protein coding gene	Chr9:44295431-44660718 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034538	protein coding gene	Chr9:48737224-49068443 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035253	protein coding gene	Chr9:43563193-43889167 (+)
PWK/PhJ	MGP_PWKPhJ_G0033449	protein coding gene	Chr9:42536404-42872491 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033285	protein coding gene	Chr9:43859769-44210829 (+)
WSB/EiJ	MGP_WSBEiJ_G0033857	protein coding gene	Chr9:43592578-43939788 (+)

Human Ortholog

DSCAML1, DS cell adhesion molecule like 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DSCAML1, DS cell adhesion molecule like 1
Synonyms

DSCAM2
Links

HGNC:14656

NCBI Gene ID: 57453

neXtProt AC: NX_Q8TD84

UniProt: Q8TD84
Chr Location

11q23.3; chr11:117427772-117817525 (-) GRCh38

MGI Vertebrate Homology

Dscaml1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DSCAML1
Gene Tree

Dscaml1

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Gene trapped

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit impaired self-avoidance in multiple cell types in the retina.

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

860
Tissues

68
cDNA Data

42
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dscaml1

ZFIN dscaml1

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All Sequences

68
RefSeq

8
UniProt

11
CCDS

CCDS40608.1

Ensembl

ENSMUSG00000032087 (Evidence)
NCBI Gene

114873

			Length	Strain/Species	Flank
genomic	114873	NCBI Gene Model \| MGI Sequence Detail	326277	C57BL/6J	± kb
transcript	NM_001081270	RefSeq \| MGI Sequence Detail	6825	C57BL/6
polypeptide	Q4VA61	UniProt \| EBI \| MGI Sequence Detail	2053	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000006696 cell adhesion molecule DSCAML1

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain
GlyGen

Q4VA61 19 sites, 14 N-linked glycans (15 sites)

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All nucleic 47

cDNA 46

Primer pair 1

Microarray probesets 5

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MGI:1918065, MGI:1921906, MGI:2143375

Summaries

All 41

Developmental Gene Expression 8

Gene Ontology 5

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:342562 Clemons MR, et al., The rod synapse in aging wildtype and Dscaml1 mutant mice. PLoS One. 2023;18(11):e0290257

TSS for Dscaml1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84799	Chr9:45337928-45337946 (+)	-798 bp
Tssr84800	Chr9:45341614-45341677 (+)	2,911 bp
Tssr84801	Chr9:45342627-45342637 (+)	3,897 bp
Tssr84802	Chr9:45342655-45342664 (+)	3,925 bp
Tssr84803	Chr9:45387634-45387639 (+)	48,902 bp
Tssr84804	Chr9:45411642-45411654 (+)	72,913 bp
Tssr84805	Chr9:45506977-45507023 (+)	168,265 bp
Tssr84806	Chr9:45508869-45508912 (+)	170,156 bp
Tssr84807	Chr9:45653871-45653883 (+)	315,142 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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