S1pr5 MGI Mouse Gene Detail - MGI:2150641 - sphingosine-1-phosphate receptor 5

Symbol

S1pr5
Name

sphingosine-1-phosphate receptor 5
Synonyms

Edg8, lpB4, S1P5

Feature Type

protein coding gene
IDs

MGI:2150641
NCBI Gene: 94226
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:21154213-21159739 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.75 cM, cytoband A4
Mapping Data

2 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2150641	protein coding gene	Chr9:21154208-21159739 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034445	protein coding gene	Chr9:18436393-18442973 (-)
A/J	MGP_AJ_G0034423	protein coding gene	Chr9:18128725-18134296 (-)
AKR/J	MGP_AKRJ_G0034350	protein coding gene	Chr9:18456010-18463008 (-)
BALB/cJ	MGP_BALBcJ_G0034414	protein coding gene	Chr9:18020770-18026143 (-)
C3H/HeJ	MGP_C3HHeJ_G0034126	protein coding gene	Chr9:18765329-18770773 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034935	protein coding gene	Chr9:19177709-19183208 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031865	protein coding gene	Chr9:17255618-17261632 (-)
CAST/EiJ	MGP_CASTEiJ_G0033449	protein coding gene	Chr9:18593664-18598599 (-)
CBA/J	MGP_CBAJ_G0034099	protein coding gene	Chr9:19903401-19908878 (-)
DBA/2J	MGP_DBA2J_G0034258	protein coding gene	Chr9:18103085-18108277 (-)
FVB/NJ	MGP_FVBNJ_G0034201	protein coding gene	Chr9:17631428-17636940 (-)
LP/J	MGP_LPJ_G0034343	protein coding gene	Chr9:18611851-18618796 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034244	protein coding gene	Chr9:21508755-21516239 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034955	protein coding gene	Chr9:18416165-18421145 (-)
PWK/PhJ	MGP_PWKPhJ_G0033155	protein coding gene	Chr9:18084295-18090101 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032989	protein coding gene	Chr9:18466265-18473335 (-)
WSB/EiJ	MGP_WSBEiJ_G0033564	protein coding gene	Chr9:18140318-18145518 (-)

Human Ortholog

S1PR5, sphingosine-1-phosphate receptor 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

S1PR5, sphingosine-1-phosphate receptor 5
Synonyms

Edg-8, EDG8, S1P5, SPPR-1, SPPR-2
Links

HGNC:14299

NCBI Gene ID: 53637

neXtProt AC: NX_Q9H228

UniProt: Q9H228
Chr Location

19p13.2; chr19:10512742-10517965 (-) GRCh38

MGI Vertebrate Homology

S1pr5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: S1PR5
Gene Tree

S1pr5

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Phenotype Summary

5 phenotypes from 2 alleles in 3 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Bone marrow from mice homozygous for a knock-out allele induces impaired NK cell egression from the lymph nodes and bone marrow.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

76
cDNA Data

9
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase s1pr5

ZFIN s1pr5a, s1pr5b

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS22898.1

Ensembl

ENSMUSG00000045087 (Evidence)
NCBI Gene

94226

			Length	Strain/Species	Flank
genomic	94226	NCBI Gene Model \| MGI Sequence Detail	5527	C57BL/6J	± kb
transcript	NM_053190	RefSeq \| MGI Sequence Detail	2512	C57BL/6
polypeptide	Q91X56	UniProt \| EBI \| MGI Sequence Detail	400	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001710 sphingosine 1-phosphate receptor 5

(term hierarchy)
InterPro Domains

IPR005386 EDG-8 sphingosine 1-phosphate receptor

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR004061 Sphingosine 1-phosphate receptor
GlyGen

Q91X56 1 site, 1 N-linked glycan (1 site)

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All nucleic 14

cDNA 9

Primer pair 3

Other 2

Microarray probesets 3

Summaries

All 62

Developmental Gene Expression 13

Gene Ontology 7

Phenotypes 22
Earliest

J:71372 Ishii I, et al., Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 2001 Sep 7;276(36):33697-704
Latest

J:352543 Delconte RB, et al., Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity. Immunity. 2024 Jun 12;

TSS for S1pr5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88389	Chr9:21159733-21159746 (-)	-1 bp
Tssr88388	Chr9:21159706-21159718 (-)	27 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24