Cnnm2 MGI Mouse Gene Detail - MGI:2151054

Symbol

Cnnm2
Name

cyclin M2
Synonyms

Acdp2

Feature Type

protein coding gene
IDs

MGI:2151054
NCBI Gene: 94219
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr19:46750035-46868631 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.97 cM
Mapping Data

2 experiments

SNPs within 2kb

3185 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151054	protein coding gene	Chr19:46745273-46868631 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025217	protein coding gene	Chr19:46521011-46641627 (+)
A/J	MGP_AJ_G0025193	protein coding gene	Chr19:44188319-44308814 (+)
AKR/J	MGP_AKRJ_G0025162	protein coding gene	Chr19:45632501-45753413 (+)
BALB/cJ	MGP_BALBcJ_G0025188	protein coding gene	Chr19:44242690-44360619 (+)
C3H/HeJ	MGP_C3HHeJ_G0024948	protein coding gene	Chr19:45809292-45939668 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025631	protein coding gene	Chr19:47647031-47766021 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023045	protein coding gene	Chr19:43425878-43545771 (+)
CAST/EiJ	MGP_CASTEiJ_G0024413	protein coding gene	Chr19:45627931-45753487 (+)
CBA/J	MGP_CBAJ_G0024928	protein coding gene	Chr19:50056656-50182205 (+)
DBA/2J	MGP_DBA2J_G0025060	protein coding gene	Chr19:44005161-44121975 (+)
FVB/NJ	MGP_FVBNJ_G0025021	protein coding gene	Chr19:43798578-43916784 (+)
LP/J	MGP_LPJ_G0025146	protein coding gene	Chr19:46415911-46535007 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025052	protein coding gene	Chr19:49367220-49487288 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025689	protein coding gene	Chr19:45750385-45872357 (+)
PWK/PhJ	MGP_PWKPhJ_G0024162	protein coding gene	Chr19:43964052-44083375 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023966	protein coding gene	Chr19:44396082-44526630 (+)
WSB/EiJ	MGP_WSBEiJ_G0024483	protein coding gene	Chr19:45900208-46025919 (+)

Human Ortholog

CNNM2, cyclin and CBS domain divalent metal cation transport mediator 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNNM2, cyclin and CBS domain divalent metal cation transport mediator 2
Synonyms

ACDP2, HOMG6, HOMGSMR
Links

HGNC:103

NCBI Gene ID: 54805

neXtProt AC: NX_Q9H8M5

UniProt: Q9H8M5
Chr Location

10q24.32; chr10:102918294-103090222 (+) GRCh38

MGI Vertebrate Homology

Cnnm2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CNNM2
Gene Tree

Cnnm2

Diseases

1 with human CNNM2 associations

				Human Disease	Mouse Models
				renal hypomagnesemia 6 IDs renal hypomagnesemia 6 DOID:0060884 ICD10CM:E83.4 OMIM:613882 ORDO:34527

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

98
Endonuclease-mediated

4
Gene trapped

88
Targeted

6
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

98 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Constitutive homozygous knockout is embryonic lethal. Homozygous KO in kidney leads to reduced serum magnesium levels and lower blood pressure.

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All GO Annotations

13
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

788
Tissues

43
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnnm2

ZFIN cnnm2a, cnnm2b

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All Sequences

54
RefSeq

7
UniProt

2
CCDS

CCDS50459.1, CCDS50460.1

Ensembl

ENSMUSG00000064105 (Evidence)
NCBI Gene

94219

			Length	Strain/Species	Flank
genomic	ENSMUSG00000064105	Ensembl Gene Model \| MGI Sequence Detail	118597	C57BL/6J	± kb
transcript	ENSMUST00000099373	Ensembl \| MGI Sequence Detail	4955	Not Applicable
polypeptide	ENSMUSP00000096972	Ensembl \| MGI Sequence Detail	875	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005644 metal transporter CNNM2

(term hierarchy)
PDB

4P1G, 4P1O, 5LXQ, 5MMZ, 6WUS
InterPro Domains

IPR045095 Ancient conserved domain protein family

IPR000644 CBS domain

IPR046342 CBS domain superfamily

IPR002550 CNNM, transmembrane domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR044751 Ion transporter-like, CBS domain

IPR014710 RmlC-like jelly roll fold
GlyGen

Q3TWN3 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 5

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MGI:2147641, MGI:2147691

Summaries

All 45

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 16
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cnnm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156807	Chr19:46749841-46749855 (+)	-187 bp
Tssr156808	Chr19:46750017-46750057 (+)	2 bp
Tssr156809	Chr19:46750066-46750077 (+)	37 bp
Tssr156810	Chr19:46750078-46750095 (+)	52 bp
Tssr156811	Chr19:46750266-46750288 (+)	242 bp
Tssr156812	Chr19:46751866-46751870 (+)	1,833 bp
Tssr156813	Chr19:46760849-46760860 (+)	10,820 bp
Tssr156814	Chr19:46807934-46807977 (+)	57,921 bp
Tssr156815	Chr19:46835287-46835299 (+)	85,258 bp
Tssr156816	Chr19:46852324-46852333 (+)	102,294 bp
Tssr156817	Chr19:46852342-46852361 (+)	102,317 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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