Cnnm4 MGI Mouse Gene Detail - MGI:2151060

Symbol

Cnnm4
Name

cyclin M4
Synonyms

5430430O18Rik, Acdp4

Feature Type

protein coding gene
IDs

MGI:2151060
NCBI Gene: 94220
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:36510701-36547845 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 15.28 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

930 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2151060	protein coding gene	Chr1:36510678-36547857 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015924	protein coding gene	Chr1:35003492-35040614 (+)
A/J	MGP_AJ_G0015908	protein coding gene	Chr1:34069830-34107095 (+)
AKR/J	MGP_AKRJ_G0015863	protein coding gene	Chr1:34552342-34589465 (+)
BALB/cJ	MGP_BALBcJ_G0015862	protein coding gene	Chr1:33758590-33795792 (+)
C3H/HeJ	MGP_C3HHeJ_G0015695	protein coding gene	Chr1:34740318-34778719 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016315	protein coding gene	Chr1:36594719-36631797 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014037	protein coding gene	Chr1:31121043-31158769 (+)
CAST/EiJ	MGP_CASTEiJ_G0015276	protein coding gene	Chr1:34629864-34667881 (+)
CBA/J	MGP_CBAJ_G0015667	protein coding gene	Chr1:37545436-37582557 (+)
DBA/2J	MGP_DBA2J_G0015768	protein coding gene	Chr1:33404719-33442267 (+)
FVB/NJ	MGP_FVBNJ_G0015770	protein coding gene	Chr1:32923600-32961026 (+)
LP/J	MGP_LPJ_G0015838	protein coding gene	Chr1:35371645-35409234 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015790	protein coding gene	Chr1:39773767-39810816 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016362	protein coding gene	Chr1:34583210-34620366 (+)
PWK/PhJ	MGP_PWKPhJ_G0015059	protein coding gene	Chr1:33151381-33189765 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014841	protein coding gene	Chr1:34532073-34569164 (+)
WSB/EiJ	MGP_WSBEiJ_G0015338	protein coding gene	Chr1:34533832-34571887 (+)

Human Ortholog

CNNM4, cyclin and CBS domain divalent metal cation transport mediator 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNNM4, cyclin and CBS domain divalent metal cation transport mediator 4
Synonyms

ACDP4
Links

HGNC:105

NCBI Gene ID: 26504

neXtProt AC: NX_Q6P4Q7

UniProt: Q6P4Q7
Chr Location

2q11.2; chr2:96760902-96811874 (+) GRCh38

MGI Vertebrate Homology

Cnnm4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CNNM4
Gene Tree

Cnnm4

Diseases

1 with human CNNM4 associations

				Human Disease	Mouse Models
				Jalili syndrome IDs Jalili syndrome DOID:0111404 MESH:C000596385 OMIM:217080 ORDO:1873 UMLS_CUI:C3495589

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Cnnm4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit hypomagnesemia, defective amelogenesis and higher blood pressure.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

2
cDNA Data

6
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnnm4

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS14879.2

Ensembl

ENSMUSG00000037408 (Evidence)
NCBI Gene

94220

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037408	Ensembl Gene Model \| MGI Sequence Detail	37145	C57BL/6J	± kb
transcript	ENSMUST00000153128	Ensembl \| MGI Sequence Detail	4547	Not Applicable
polypeptide	ENSMUSP00000121317	Ensembl \| MGI Sequence Detail	771	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000005646 metal transporter CNNM4

(term hierarchy)
InterPro Domains

IPR045095 Ancient conserved domain protein family

IPR000644 CBS domain

IPR046342 CBS domain superfamily

IPR002550 CNNM, transmembrane domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR044751 Ion transporter-like, CBS domain

IPR014710 RmlC-like jelly roll fold
GlyGen

Q69ZF7 5 sites, 10 N-linked glycans (5 sites)

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 5

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MGI:1921746

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 15
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cnnm4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6267	Chr1:36510671-36510687 (+)	-22 bp
Tssr6268	Chr1:36529232-36529235 (+)	18,533 bp
Tssr6269	Chr1:36531790-36531817 (+)	21,103 bp
Tssr6270	Chr1:36545939-36545943 (+)	35,240 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24