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Dgcr8 Gene Detail
Summary
  • Symbol
    Dgcr8
  • Name
    DGCR8, microprocessor complex subunit
  • Synonyms
    D16H22S1742E, D16H22S788E, D16Wis2, DiGeorge syndrome critical region gene 8, Gy1, N41, Vo59c07
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151114
    NCBI Gene: 94223
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18071812-18107110 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.31 cM, cytoband B1
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151114
 protein coding gene Chr16:18071812-18107115 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022607
 protein coding gene Chr16:15461212-15504653 (-)
A/J MGP_AJ_G0022568
 protein coding gene Chr16:14697796-14733316 (-)
AKR/J MGP_AKRJ_G0022545
 protein coding gene Chr16:15275841-15313738 (-)
BALB/cJ MGP_BALBcJ_G0022573
 protein coding gene Chr16:14847157-14882874 (-)
C3H/HeJ MGP_C3HHeJ_G0022340
 protein coding gene Chr16:15439489-15476644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023022
 protein coding gene Chr16:15731401-15774346 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020542
 protein coding gene Chr16:14748673-14782879 (-)
CAST/EiJ MGP_CASTEiJ_G0021867
 protein coding gene Chr16:15328019-15365249 (-)
CBA/J MGP_CBAJ_G0022309
 protein coding gene Chr16:16417316-16470467 (-)
DBA/2J MGP_DBA2J_G0022441
 protein coding gene Chr16:14609191-14645558 (-)
FVB/NJ MGP_FVBNJ_G0022416
 protein coding gene Chr16:14666514-14716623 (-)
LP/J MGP_LPJ_G0022508
 protein coding gene Chr16:15245076-15282507 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022438
 protein coding gene Chr16:16068912-16110227 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023033
 protein coding gene Chr16:15212911-15252133 (-)
PWK/PhJ MGP_PWKPhJ_G0021609
 protein coding gene Chr16:14879736-14917920 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021437
 protein coding gene Chr16:15181559-15210780 (-)
WSB/EiJ MGP_WSBEiJ_G0021913
 protein coding gene Chr16:15196118-15242643 (-)



Homology
more
  • Human Ortholog
    DGCR8, DGCR8 microprocessor complex subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGCR8, DGCR8 microprocessor complex subunit
  • Synonyms
    C22orf12, DGCRK6, Gy1, pasha
  • Links
    NCBI Gene ID: 54487
    neXtProt AC: NX_Q8WYQ5
    UniProt: Q8WYQ5

  • Chr Location
    22q11.21; chr22:20080221-20111877 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DGCR8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 5 alleles in 8 genetic backgrounds
    201 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a gene trap allele exhibit reduced dendritic spine number and dendritiic complexity along with abnormal prepulse inhibition and abnormal spatial working memory. Homozygous mice are embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    70
  • cDNA Data
    13
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022718 Ensembl Gene Model | MGI Sequence Detail 35299 C57BL/6J ±  kb
    transcript ENSMUST00000009321 Ensembl | MGI Sequence Detail 4320 Not Applicable  
    polypeptide ENSMUSP00000009321 Ensembl | MGI Sequence Detail 773 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 15
      cDNA 18
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1098823, MGI:1202891, MGI:1927907, MGI:892900
    References
    more
    • Summaries
      All 252
      Developmental Gene Expression 15
      Diseases 6
      Gene Ontology 10
      Phenotypes 201
    • Earliest
      J:38193 Galili N, et al., A region of mouse chromosome 16 is syntenic to the DiGeorge, velocardiofacial syndrome minimal critical region. (Correction: vol. 7(4):399). Genome Res. 1997 Jan;7(1):17-26
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory