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Stim2 Gene Detail
Summary
  • Symbol
    Stim2
  • Name
    stromal interaction molecule 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151156
    NCBI Gene: 116873
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:54155865-54278399 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 29.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3172 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151156
 protein coding gene Chr5:54155841-54278399 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029557
 protein coding gene Chr5:53085941-53216574 (+)
A/J MGP_AJ_G0029525
 protein coding gene Chr5:51214359-51340066 (+)
AKR/J MGP_AKRJ_G0029473
 protein coding gene Chr5:52966267-53090682 (+)
BALB/cJ MGP_BALBcJ_G0029534
 protein coding gene Chr5:51694656-51818646 (+)
C3H/HeJ MGP_C3HHeJ_G0029257
 protein coding gene Chr5:53127050-53258072 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029988
 protein coding gene Chr5:55241992-55371894 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027228
 protein coding gene Chr5:47928890-48047878 (+)
CAST/EiJ MGP_CASTEiJ_G0028665
 protein coding gene Chr5:52110740-52241816 (+)
CBA/J MGP_CBAJ_G0029226
 protein coding gene Chr5:57007518-57145064 (+)
DBA/2J MGP_DBA2J_G0029372
 protein coding gene Chr5:51261483-51391214 (+)
FVB/NJ MGP_FVBNJ_G0029332
 protein coding gene Chr5:50588321-50713153 (+)
LP/J MGP_LPJ_G0029457
 protein coding gene Chr5:53521892-53662719 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029360
 protein coding gene Chr5:58002825-58138737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030021
 protein coding gene Chr5:52462483-52592916 (+)
PWK/PhJ MGP_PWKPhJ_G0028389
 protein coding gene Chr5:50328117-50449995 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028223
 protein coding gene Chr5:51903416-52083026 (+)
WSB/EiJ MGP_WSBEiJ_G0028746
 protein coding gene Chr5:52515413-52643783 (+)



Homology
more
  • Human Ortholog
    STIM2, stromal interaction molecule 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STIM2, stromal interaction molecule 2
  • Links
    NCBI Gene ID: 57620
    neXtProt AC: NX_Q9P246
    UniProt: Q9P246

  • Chr Location
    4p15.2; chr4:26857601-27025381 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 5 genetic backgrounds
    33 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight growth delay and premature death while embryonic fibroblasts show reduced store-operated Ca2+ influx. Mice homozygous for a different null allele show increased neuron survival under hypoxic conditions and resistance to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    24
  • cDNA Data
    66
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116873 NCBI Gene Model | MGI Sequence Detail 122535 C57BL/6J ±  kb
    transcript NM_001363348 RefSeq | MGI Sequence Detail 4934 ZRU/MplStud  
    polypeptide P83093 UniProt | EBI | MGI Sequence Detail 746 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000015737 stromal interaction molecule 2
      (term hierarchy)
    • InterPro Domains
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR037608 Stromal interaction molecule
      IPR037610 Stromal interaction molecule 2, SAM domain
      IPR032393 Stromal interaction molecule, Orai1-activating region
    • GlyGen
      P83093 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 66
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 66
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:350991 Woo MS, et al., STING orchestrates the neuronal inflammatory stress response in multiple sclerosis. Cell. 2024 Jun 7;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory