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Selenon Gene Detail
Summary
  • Symbol
    Selenon
  • Name
    selenoprotein N
  • Synonyms
    1110019I12Rik, Sepn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151208
    NCBI Gene: 74777
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134265203-134279477 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.85 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    531 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151208
 protein coding gene Chr4:134265203-134279477 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028931
 protein coding gene Chr4:136899624-136915588 (-)
A/J MGP_AJ_G0028890
 protein coding gene Chr4:131141389-131156616 (-)
AKR/J MGP_AKRJ_G0028842
 protein coding gene Chr4:134906789-134921101 (-)
BALB/cJ MGP_BALBcJ_G0028914
 protein coding gene Chr4:131788974-131803280 (-)
C3H/HeJ MGP_C3HHeJ_G0028628
 protein coding gene Chr4:135150279-135164591 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029355
 protein coding gene Chr4:141839365-141855213 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026626
 protein coding gene Chr4:124196546-124210995 (-)
CAST/EiJ MGP_CASTEiJ_G0028060
 protein coding gene Chr4:133267380-133281724 (-)
CBA/J MGP_CBAJ_G0028593
 protein coding gene Chr4:145584501-145604935 (-)
DBA/2J MGP_DBA2J_G0028742
 protein coding gene Chr4:131562390-131577069 (-)
FVB/NJ MGP_FVBNJ_G0028709
 protein coding gene Chr4:130461952-130476189 (-)
LP/J MGP_LPJ_G0028841
 protein coding gene Chr4:137011772-137026120 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028735
 protein coding gene Chr4:150055005-150070846 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029393
 protein coding gene Chr4:135344405-135358792 (-)
PWK/PhJ MGP_PWKPhJ_G0027780
 protein coding gene Chr4:128293907-128309967 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027606
 protein coding gene Chr4:131157627-131172071 (-)
WSB/EiJ MGP_WSBEiJ_G0028138
 protein coding gene Chr4:135509143-135526172 (-)



Homology
more
  • Human Ortholog
    SELENON, selenoprotein N
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SELENON, selenoprotein N
  • Synonyms
    CFTD, CMYO3, CMYP3, MDRS1, RSMD1, RSS, SELN, SEPN1
  • Links
    NCBI Gene ID: 57190
    neXtProt AC: NX_Q9NZV5
    UniProt: Q9NZV5

  • Chr Location
    1p36.11; chr1:25800193-25818221 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Selenon mouse models; 1 with human SELENON associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit satellite cell loss and impaired muscle regeneration. Mice homozygous for a different knock-out allele exhibit subtle core lesions in skeletal muscle after induced oxidative stress and abnormal lung development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    55
  • cDNA Data
    76
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74777 NCBI Gene Model | MGI Sequence Detail 14275 C57BL/6J ±  kb
    transcript NM_029100 RefSeq | MGI Sequence Detail 3461 C57BL/6  
    polypeptide D3Z2R5 UniProt | EBI | MGI Sequence Detail 557 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 76
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922027, MGI:2140256
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:356241 Germani S, et al., SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA. Cell Rep Med. 2024 Mar 19;5(3):101439
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory