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Tirap Gene Detail
Summary
  • Symbol
    Tirap
  • Name
    toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  • Synonyms
    C130027E04Rik, Mal, Mal, MyD88-adapter-like, wyatt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152213
    NCBI Gene: 117149
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:35095847-35111587 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 19.99 cM, cytoband A5.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152213
 protein coding gene Chr9:35095687-35111587 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034530
 protein coding gene Chr9:32989161-33004884 (-)
A/J MGP_AJ_G0034508
 protein coding gene Chr9:32135435-32151525 (-)
AKR/J MGP_AKRJ_G0034434
 protein coding gene Chr9:32856200-32875034 (-)
BALB/cJ MGP_BALBcJ_G0034499
 protein coding gene Chr9:32052072-32067776 (-)
C3H/HeJ MGP_C3HHeJ_G0034211
 protein coding gene Chr9:33194323-33211260 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035020
 protein coding gene Chr9:34100767-34116596 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031950
 protein coding gene Chr9:30822816-30840224 (-)
CAST/EiJ MGP_CASTEiJ_G0033534
 protein coding gene Chr9:33083183-33101684 (-)
CBA/J MGP_CBAJ_G0034185
 protein coding gene Chr9:35250766-35267054 (-)
DBA/2J MGP_DBA2J_G0034342
 protein coding gene Chr9:32117246-32133071 (-)
FVB/NJ MGP_FVBNJ_G0034285
 protein coding gene Chr9:31531349-31547050 (-)
LP/J MGP_LPJ_G0034428
 protein coding gene Chr9:33239674-33256155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034329
 protein coding gene Chr9:36823980-36840786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035040
 protein coding gene Chr9:32807820-32824731 (-)
PWK/PhJ MGP_PWKPhJ_G0033239
 protein coding gene Chr9:32102466-32118805 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033074
 protein coding gene Chr9:32955120-32974269 (-)
WSB/EiJ MGP_WSBEiJ_G0033649
 protein coding gene Chr9:32577100-32593743 (-)



Homology
more
  • Human Ortholog
    TIRAP, TIR domain containing adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIRAP, TIR domain containing adaptor protein
  • Synonyms
    BACTS1, Mal, MyD88-2, wyatt
  • Links
    NCBI Gene ID: 114609
    neXtProt AC: NX_P58753
    UniProt: P58753

  • Chr Location
    11q24.2; chr11:126282497-126298845 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TIRAP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene lead to impaired cytokine secretion in response to TLR2 and TLR4 ligands. Homozygous null mice may also show low serum IgG3 levels, a reduced response to attenuated yellow fever vaccine, high susceptibility to bacterial infection, and altered response to myocardial infarction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    39
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032041 Ensembl Gene Model | MGI Sequence Detail 15741 C57BL/6J ±  kb
    transcript ENSMUST00000175765 Ensembl | MGI Sequence Detail 4589 Not Applicable  
    polypeptide ENSMUSP00000135435 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
      (term hierarchy)
    • InterPro Domains
      IPR017279 Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
      IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
      IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142915
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 2
      Gene Ontology 18
      Phenotypes 66
    • Earliest
      J:71392 Fitzgerald KA, et al., Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83
    • Latest
      J:329488 Gopal A, et al., TIRAP drives myelosuppression through an Ifngamma-Hmgb1 axis that disrupts the endothelial niche in mice. J Exp Med. 2022 Mar 7;219(3):e20200731
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory