Taf4b MGI Mouse Gene Detail - MGI:2152345 - TATA-box binding protein associated factor 4b

Symbol

Taf4b
Name

TATA-box binding protein associated factor 4b
Synonyms

105kDa, 2610524B04Rik, 4932409F03Rik, Taf2c2, TAFII105

Feature Type

protein coding gene
IDs

MGI:2152345
NCBI Gene: 72504
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:14916302-15033416 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 8.28 cM
Mapping Data

2 experiments

SNPs within 2kb

2224 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152345	protein coding gene	Chr18:14916302-15035160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024170	protein coding gene	Chr18:12071875-12196131 (+)
A/J	MGP_AJ_G0024132	protein coding gene	Chr18:11822973-11943793 (+)
AKR/J	MGP_AKRJ_G0024099	protein coding gene	Chr18:12217094-12346463 (+)
BALB/cJ	MGP_BALBcJ_G0024131	protein coding gene	Chr18:11763691-11884980 (+)
C3H/HeJ	MGP_C3HHeJ_G0023898	protein coding gene	Chr18:12057323-12180039 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024576	protein coding gene	Chr18:12663774-12784930 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022016	protein coding gene	Chr18:11325451-11445141 (+)
CAST/EiJ	MGP_CASTEiJ_G0023375	protein coding gene	Chr18:11959245-12086248 (+)
CBA/J	MGP_CBAJ_G0023870	protein coding gene	Chr18:12824165-12958886 (+)
DBA/2J	MGP_DBA2J_G0023999	protein coding gene	Chr18:11643526-11762190 (+)
FVB/NJ	MGP_FVBNJ_G0023964	protein coding gene	Chr18:11485435-11601089 (+)
LP/J	MGP_LPJ_G0024082	protein coding gene	Chr18:12186687-12308205 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023993	protein coding gene	Chr18:12950959-13086295 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024622	protein coding gene	Chr18:11956152-12076459 (+)
PWK/PhJ	MGP_PWKPhJ_G0023121	protein coding gene	Chr18:11748017-11866651 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022930	protein coding gene	Chr18:12221152-12339965 (+)
WSB/EiJ	MGP_WSBEiJ_G0023441	protein coding gene	Chr18:11924568-12045295 (+)

Human Ortholog

TAF4B, TATA-box binding protein associated factor 4b

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TAF4B, TATA-box binding protein associated factor 4b
Synonyms

SPGF13, TAF2C2, TAFII105
Links

HGNC:11538

NCBI Gene ID: 6875

neXtProt AC: NX_Q92750

UniProt: Q92750
Chr Location

18q11.2; chr18:26226445-26391685 (+) GRCh38

MGI Vertebrate Homology

Taf4b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TAF4B
Gene Tree

Taf4b

Diseases

1 with human TAF4B associations

				Human Disease	Mouse Models
				spermatogenic failure 13 IDs spermatogenic failure 13 DOID:0070182 OMIM:615841

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

35 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Gene trapped

6
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null male mice are initially fertile but show progressive germ cell loss, seminiferous tubule degeneration and spermatogonia defects leading to sterility. Females are sterile and show premature ovarian aging, persistent estrous, elevated FSH levels and reduced primordial follicle numbers.

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

836
Tissues

118
cDNA Data

44
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase taf4b

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All Sequences

44
RefSeq

6
UniProt

4
CCDS

CCDS50227.1, CCDS89195.1

Ensembl

ENSMUSG00000054321 (Evidence)
NCBI Gene

72504

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054321	Ensembl Gene Model \| MGI Sequence Detail	117115	C57BL/6J	± kb
transcript	ENSMUST00000169862	Ensembl \| MGI Sequence Detail	5149	Not Applicable
polypeptide	ENSMUSP00000126909	Ensembl \| MGI Sequence Detail	855	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016027 transcription initiation factor TFIID subunit 4

(term hierarchy)
InterPro Domains

IPR009072 Histone-fold

IPR003894 TAFH/NHR1

IPR037249 TAFH/NHR1 domain superfamily

IPR045144 Transcription initiation factor TFIID component TAF4

IPR007900 Transcription initiation factor TFIID component TAF4, C-terminal
GlyGen

G5E8Z2 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 47

cDNA 44

Primer pair 3

Microarray probesets 6

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MGI:1919754, MGI:2147380

Summaries

All 59

Developmental Gene Expression 14

Gene Ontology 9

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:342170 Gura MA, et al., Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia. Front Cell Dev Biol. 2023;11:1270408

TSS for Taf4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150133	Chr18:14916251-14916278 (+)	-37 bp
Tssr150134	Chr18:14916295-14916316 (+)	4 bp
Tssr150135	Chr18:14981063-14981064 (+)	64,762 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24