Ivns1abp MGI Mouse Gene Detail - MGI:2152389 - influenza virus NS1A binding protein

Symbol

Ivns1abp
Name

influenza virus NS1A binding protein
Synonyms

1190004M08Rik, 1700126I16Rik, HSPC068, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP

Feature Type

protein coding gene
IDs

MGI:2152389
NCBI Gene: 117198
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:151220228-151240173 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 64.06 cM
Mapping Data

2 experiments

SNPs within 2kb

441 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152389	protein coding gene	Chr1:151220228-151240196 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016579	protein coding gene	Chr1:156066619-156088672 (+)
A/J	MGP_AJ_G0016561	protein coding gene	Chr1:149763664-149783629 (+)
AKR/J	MGP_AKRJ_G0016526	protein coding gene	Chr1:154375665-154395671 (+)
BALB/cJ	MGP_BALBcJ_G0016521	protein coding gene	Chr1:150325527-150345466 (+)
C3H/HeJ	MGP_C3HHeJ_G0016346	protein coding gene	Chr1:154517442-154537398 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016982	protein coding gene	Chr1:161467203-161487148 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014691	protein coding gene	Chr1:142108885-142128955 (+)
CAST/EiJ	MGP_CASTEiJ_G0015925	protein coding gene	Chr1:153946628-153966296 (+)
CBA/J	MGP_CBAJ_G0016320	protein coding gene	Chr1:167145495-167165461 (+)
DBA/2J	MGP_DBA2J_G0016426	protein coding gene	Chr1:148813762-148833709 (+)
FVB/NJ	MGP_FVBNJ_G0016424	protein coding gene	Chr1:147266507-147286458 (+)
LP/J	MGP_LPJ_G0016497	protein coding gene	Chr1:157120369-157140280 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016450	protein coding gene	Chr1:174860670-174880620 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017018	protein coding gene	Chr1:154144086-154164040 (+)
PWK/PhJ	MGP_PWKPhJ_G0015711	protein coding gene	Chr1:147772336-147792573 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015498	protein coding gene	Chr1:152982716-153003715 (+)
WSB/EiJ	MGP_WSBEiJ_G0015988	protein coding gene	Chr1:154245569-154265525 (+)

Human Ortholog

IVNS1ABP, influenza virus NS1A binding protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IVNS1ABP, influenza virus NS1A binding protein
Synonyms

ARA3, FLARA3, HSPC068, IMD70, KLHL39, ND1, NS-1, NS1-BP, NS1BP
Links

HGNC:16951

NCBI Gene ID: 10625

neXtProt AC: NX_Q9Y6Y0

UniProt: Q9Y6Y0
Chr Location

1q25.3; chr1:185292931-185317273 (-) GRCh38

MGI Vertebrate Homology

Ivns1abp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IVNS1ABP
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Ivns1abp

Diseases

1 with human IVNS1ABP associations

				Human Disease	Mouse Models
				immunodeficiency 70 IDs immunodeficiency 70 DOID:0112005 OMIM:618969

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

3
Targeted

2
Genomic Mutations

2 involving Ivns1abp
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit some early lethality, increased cellular sensitivity to cytochalasin and doxorubicin, and doxorubicin-induced cardiotoxicity.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1033
Tissues

50
cDNA Data

419
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA IVNS1ABP

Xenbase ivns1abp

ZFIN ivns1abpa

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All Sequences

78
RefSeq

14
UniProt

3
CCDS

CCDS15358.1, CCDS15359.1, CCDS35735.1

Ensembl

ENSMUSG00000023150 (Evidence)
NCBI Gene

117198

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023150	Ensembl Gene Model \| MGI Sequence Detail	19946	C57BL/6J	± kb
transcript	ENSMUST00000023918	Ensembl \| MGI Sequence Detail	3511	Not Applicable
polypeptide	ENSMUSP00000023918	Ensembl \| MGI Sequence Detail	642	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009168 influenza virus NS1A-binding protein

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 421

cDNA 421

Microarray probesets 5

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MGI:1916149, MGI:1920854, MGI:2138140

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 8
Earliest

J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Ivns1abp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9377	Chr1:151219761-151219784 (+)	-455 bp
Tssr9378	Chr1:151220199-151220209 (+)	-24 bp
Tssr9379	Chr1:151220223-151220281 (+)	24 bp
Tssr9380	Chr1:151220282-151220335 (+)	81 bp
Tssr9381	Chr1:151221252-151221263 (+)	1,030 bp
Tssr9382	Chr1:151230736-151230742 (+)	10,511 bp
Tssr9383	Chr1:151233821-151233824 (+)	13,595 bp
Tssr9384	Chr1:151235764-151235774 (+)	15,541 bp
Tssr9385	Chr1:151238811-151238815 (+)	18,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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