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Trim66 Gene Detail
Summary
  • Symbol
    Trim66
  • Name
    tripartite motif-containing 66
  • Synonyms
    D7H11orf29, Tif1d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152406
    NCBI Gene: 330627
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109048213-109107341 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1810 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152406
 protein coding gene Chr7:109048208-109115948 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032841
 protein coding gene Chr7:112869843-112936526 (-)
A/J MGP_AJ_G0032825
 protein coding gene Chr7:110089648-110149757 (-)
AKR/J MGP_AKRJ_G0032756
 protein coding gene Chr7:112840153-112916207 (-)
BALB/cJ MGP_BALBcJ_G0032829
 protein coding gene Chr7:109785876-109846889 (-)
C3H/HeJ MGP_C3HHeJ_G0032539
 protein coding gene Chr7:112885364-112945628 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033335
 protein coding gene Chr7:117561887-117621597 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030308
 protein coding gene Chr7:111660781-111721068 (-)
CAST/EiJ MGP_CASTEiJ_G0031867
 protein coding gene Chr7:104408409-104473262 (-)
CBA/J MGP_CBAJ_G0032512
 protein coding gene Chr7:121408112-121481109 (-)
DBA/2J MGP_DBA2J_G0032664
 protein coding gene Chr7:108201619-108260969 (-)
FVB/NJ MGP_FVBNJ_G0032617
 protein coding gene Chr7:108046530-108107256 (-)
LP/J MGP_LPJ_G0032758
 protein coding gene Chr7:114406721-114466910 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032649
 protein coding gene Chr7:123076082-123139917 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033356
 protein coding gene Chr7:111859294-111922753 (-)
PWK/PhJ MGP_PWKPhJ_G0031574
 protein coding gene Chr7:100996784-101058464 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031422
 protein coding gene Chr7:98542092-98606751 (-)
WSB/EiJ MGP_WSBEiJ_G0031980
 protein coding gene Chr7:112692332-112765634 (-)



Homology
more
  • Human Ortholog
    TRIM66, tripartite motif containing 66
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM66, tripartite motif containing 66
  • Synonyms
    C11orf29, TIF1D, TIF1DELTA
  • Links
    NCBI Gene ID: 9866
    neXtProt AC: NX_O15016
    UniProt: O15016

  • Chr Location
    11p15.4; chr11:8612037-8683231 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males, but not females, sire pups that are overweight at birth, indicating a paternal effect on intrauterine overgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    1
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031026 Ensembl Gene Model | MGI Sequence Detail 59129 C57BL/6J ±  kb
    transcript ENSMUST00000106741 Ensembl | MGI Sequence Detail 4417 Not Applicable  
    polypeptide ENSMUSP00000102352 Ensembl | MGI Sequence Detail 1344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 21
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:349240 Mielnicka M, et al., Trim66's paternal deficiency causes intrauterine overgrowth. Life Sci Alliance. 2024 Jul;7(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory