Asb10 MGI Mouse Gene Detail - MGI:2152836 - ankyrin repeat and SOCS box-containing 10

Symbol

Asb10
Name

ankyrin repeat and SOCS box-containing 10
Synonyms

Asb-10

Feature Type

protein coding gene
IDs

MGI:2152836
NCBI Gene: 117590
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:24737695-24745976 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 11.93 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

288 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152836	protein coding gene	Chr5:24737695-24745976 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029348	protein coding gene	Chr5:22274134-22282497 (-)
A/J	MGP_AJ_G0029314	protein coding gene	Chr5:21505798-21514067 (-)
AKR/J	MGP_AKRJ_G0029265	protein coding gene	Chr5:22369736-22380317 (-)
BALB/cJ	MGP_BALBcJ_G0029325	protein coding gene	Chr5:22022537-22030818 (-)
C3H/HeJ	MGP_C3HHeJ_G0029045	protein coding gene	Chr5:22489021-22497300 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029778	protein coding gene	Chr5:23769049-23777328 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027016	protein coding gene	Chr5:19448399-19457026 (-)
CAST/EiJ	MGP_CASTEiJ_G0028457	protein coding gene	Chr5:21665009-21673342 (-)
CBA/J	MGP_CBAJ_G0029012	protein coding gene	Chr5:24148166-24156481 (-)
DBA/2J	MGP_DBA2J_G0029163	protein coding gene	Chr5:21799455-21808597 (-)
FVB/NJ	MGP_FVBNJ_G0029121	protein coding gene	Chr5:21175501-21183785 (-)
LP/J	MGP_LPJ_G0029247	protein coding gene	Chr5:22672246-22680586 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029150	protein coding gene	Chr5:25267247-25277100 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029812	protein coding gene	Chr5:22022726-22031035 (-)
PWK/PhJ	MGP_PWKPhJ_G0028181	protein coding gene	Chr5:20880556-20888855 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028012	protein coding gene	Chr5:21368554-21376863 (-)
WSB/EiJ	MGP_WSBEiJ_G0028537	protein coding gene	Chr5:22089525-22097830 (-)

Human Ortholog

ASB10, ankyrin repeat and SOCS box containing 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ASB10, ankyrin repeat and SOCS box containing 10
Synonyms

GLC1F
Links

HGNC:17185

NCBI Gene ID: 136371

neXtProt AC: NX_Q8WXI3

UniProt: Q8WXI3
Chr Location

7q36.1; chr7:151175698-151187832 (-) GRCh38

MGI Vertebrate Homology

Asb10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ASB10
Gene Tree

Asb10

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Asb10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS19124.1, CCDS80229.1

Ensembl

ENSMUSG00000038204 (Evidence)
NCBI Gene

117590

			Length	Strain/Species	Flank
genomic	117590	NCBI Gene Model \| MGI Sequence Detail	8282	C57BL/6J	± kb
transcript	NM_080444	RefSeq \| MGI Sequence Detail	2327	C57BL/6
polypeptide	Q91ZT7	UniProt \| EBI \| MGI Sequence Detail	467	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004342 ankyrin repeat and SOCS box protein 10

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:2141266

Summaries

All 43

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Asb10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50336	Chr5:24745974-24746006 (-)	-14 bp
Tssr50335	Chr5:24745938-24745948 (-)	33 bp
Tssr50334	Chr5:24745437-24745449 (-)	533 bp
Tssr50333	Chr5:24745421-24745424 (-)	553 bp
Tssr50332	Chr5:24745411-24745420 (-)	560 bp
Tssr50331	Chr5:24745382-24745393 (-)	588 bp
Tssr50330	Chr5:24745376-24745381 (-)	597 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24