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Rims1 Gene Detail
Summary
  • Symbol
    Rims1
  • Name
    regulating synaptic membrane exocytosis 1
  • Synonyms
    C030033M19Rik, RIM1, RIM1a, RIM1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152971
    NCBI Gene: 116837
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:22356475-22845203 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 8.54 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15678 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152971
 protein coding gene Chr1:22356196-22845239 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015882
 protein coding gene Chr1:20024269-20557947 (-)
A/J MGP_AJ_G0015863
 protein coding gene Chr1:19704015-20200198 (-)
AKR/J MGP_AKRJ_G0015820
 protein coding gene Chr1:19831397-20359431 (-)
BALB/cJ MGP_BALBcJ_G0015819
 protein coding gene Chr1:19433053-19934591 (-)
C3H/HeJ MGP_C3HHeJ_G0015653
 protein coding gene Chr1:19859741-20372596 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016273
 protein coding gene Chr1:20963297-21509988 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013992
 protein coding gene Chr1:17851823-18340739 (-)
CAST/EiJ MGP_CASTEiJ_G0015232
 protein coding gene Chr1:19954864-20499828 (-)
CBA/J MGP_CBAJ_G0015625
 protein coding gene Chr1:21464033-22041469 (-)
DBA/2J MGP_DBA2J_G0015724
 protein coding gene Chr1:19205241-19706830 (-)
FVB/NJ MGP_FVBNJ_G0015728
 protein coding gene Chr1:18982553-19478909 (-)
LP/J MGP_LPJ_G0015796
 protein coding gene Chr1:20247186-20761028 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015748
 protein coding gene Chr1:22441075-23010386 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016320
 protein coding gene Chr1:19773877-20303507 (-)
PWK/PhJ MGP_PWKPhJ_G0015015
 protein coding gene Chr1:18981424-19476678 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014796
 protein coding gene Chr1:19860999-20368979 (-)
WSB/EiJ MGP_WSBEiJ_G0015295
 protein coding gene Chr1:19737729-20250478 (-)



Homology
more
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Synonyms
    CORD7, RAB3IP2, RIM, RIM1
  • Links
    NCBI Gene ID: 22999
    neXtProt AC: NX_Q86UR5
    UniProt: Q86UR5

  • Chr Location
    6q13; chr6:71886550-72403150 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    23
  • cDNA Data
    8
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      160
    • RefSeq
      100
    • UniProt
      9
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041670 Ensembl Gene Model | MGI Sequence Detail 488729 C57BL/6J ±  kb
    transcript ENSMUST00000097809 Ensembl | MGI Sequence Detail 7172 Not Applicable  
    polypeptide ENSMUSP00000095418 Ensembl | MGI Sequence Detail 1666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924723
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 8
      Gene Ontology 23
      Phenotypes 64
    • Earliest
      J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
    • Latest
      J:358058 Emperador-Melero J, et al., Distinct active zone protein machineries mediate Ca(2+) channel clustering and vesicle priming at hippocampal synapses. Nat Neurosci. 2024 Sep;27(9):1680-1694
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory