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Gjc3 Gene Detail
Summary
  • Symbol
    Gjc3
  • Name
    gap junction protein, gamma 3
  • Synonyms
    connexin 29, Cx29, Gje1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153041
    NCBI Gene: 118446
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137951723-137961360 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    353 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153041
 protein coding gene Chr5:137949254-137961360 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030250
 protein coding gene Chr5:142743507-142752979 (-)
A/J MGP_AJ_G0030216
 protein coding gene Chr5:136532730-136544936 (-)
AKR/J MGP_AKRJ_G0030151
 protein coding gene Chr5:140982967-140994490 (-)
BALB/cJ MGP_BALBcJ_G0030228
 protein coding gene Chr5:137920545-137930436 (-)
C3H/HeJ MGP_C3HHeJ_G0029944
 protein coding gene Chr5:141627517-141638163 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030680
 protein coding gene Chr5:148059096-148070192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027898
 protein coding gene Chr5:130762740-130771436 (-)
CAST/EiJ MGP_CASTEiJ_G0029352
 protein coding gene Chr5:141026810-141040151 (-)
CBA/J MGP_CBAJ_G0029914
 protein coding gene Chr5:153937128-153953063 (-)
DBA/2J MGP_DBA2J_G0030065
 protein coding gene Chr5:136461029-136470724 (-)
FVB/NJ MGP_FVBNJ_G0030020
 protein coding gene Chr5:135622969-135634148 (-)
LP/J MGP_LPJ_G0030154
 protein coding gene Chr5:143256974-143267820 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030052
 protein coding gene Chr5:156747692-156759402 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030721
 protein coding gene Chr5:140829056-140839712 (-)
PWK/PhJ MGP_PWKPhJ_G0029066
 protein coding gene Chr5:135523209-135533169 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028902
 protein coding gene Chr5:138388774-138397868 (-)
WSB/EiJ MGP_WSBEiJ_G0029427
 protein coding gene Chr5:141546247-141559457 (-)



Homology
more
  • Human Ortholog
    GJC3, gap junction protein gamma 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GJC3, gap junction protein gamma 3
  • Synonyms
    CX29, CX30.2, CX31.3, GJE1
  • Links
    NCBI Gene ID: 349149
    neXtProt AC: NX_Q8NFK1
    UniProt: Q8NFK1

  • Chr Location
    7q22.1; chr7:99923266-99930747 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Half of homozygotes for a null allele show delayed maturation of hearing thresholds, high-frequency hearing loss, vulnerability to noise damage and demyelination of spiral ganglion neurons. Homozygotes for another null allele show normal sciatic nerve conduction with no auditory or visual deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    29
  • cDNA Data
    7
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056966 Ensembl Gene Model | MGI Sequence Detail 9638 C57BL/6J ±  kb
    transcript ENSMUST00000077119 Ensembl | MGI Sequence Detail 4002 Not Applicable  
    polypeptide ENSMUSP00000076367 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:70957 Sohl G, et al., The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem. 2001 Jun;382(6):973-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory