Parvb MGI Mouse Gene Detail - MGI:2153063

Symbol

Parvb
Name

parvin, beta
Synonyms

affixin, D15Gsk1

Feature Type

protein coding gene
IDs

MGI:2153063
NCBI Gene: 170736
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:84116244-84199889 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 39.78 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

2421 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2153063	protein coding gene	Chr15:84116244-84199890 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022176	protein coding gene	Chr15:84999881-85100068 (+)
A/J	MGP_AJ_G0022135	protein coding gene	Chr15:81868726-81956108 (+)
AKR/J	MGP_AKRJ_G0022110	protein coding gene	Chr15:84256523-84348425 (+)
BALB/cJ	MGP_BALBcJ_G0022141	protein coding gene	Chr15:82004669-82089984 (+)
C3H/HeJ	MGP_C3HHeJ_G0021911	protein coding gene	Chr15:84208958-84302029 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022586	protein coding gene	Chr15:88237604-88337727 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020111	protein coding gene	Chr15:78230458-78313790 (+)
CAST/EiJ	MGP_CASTEiJ_G0021433	protein coding gene	Chr15:85005522-85103774 (+)
CBA/J	MGP_CBAJ_G0021878	protein coding gene	Chr15:91087830-91194640 (+)
DBA/2J	MGP_DBA2J_G0022005	protein coding gene	Chr15:81349413-81435234 (+)
FVB/NJ	MGP_FVBNJ_G0021984	protein coding gene	Chr15:80404029-80488144 (+)
LP/J	MGP_LPJ_G0022076	protein coding gene	Chr15:85160644-85253310 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022004	protein coding gene	Chr15:95922643-96020223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022601	protein coding gene	Chr15:84259443-84362465 (+)
PWK/PhJ	MGP_PWKPhJ_G0021174	protein coding gene	Chr15:81347356-81433877 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021008	protein coding gene	Chr15:83971607-84072685 (+)
WSB/EiJ	MGP_WSBEiJ_G0021482	protein coding gene	Chr15:84768002-84859628 (+)

Human Ortholog

PARVB, parvin beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARVB, parvin beta
Synonyms

CGI-56
Links

HGNC:14653

NCBI Gene ID: 29780

neXtProt AC: NX_Q9HBI1

UniProt: Q9HBI1
Chr Location

22q13.31; chr22:43999211-44172939 (+) GRCh38

MGI Vertebrate Homology

Parvb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PARVB
Protein SuperFamily

Parvin
Gene Tree

Parvb

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References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

23
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Parvb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

52 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Disruption of this marker has no apparent adverse consequences.

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All GO Annotations

33
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

959
Tissues

124
cDNA Data

53
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase parvb

ZFIN parvb

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All Sequences

48
RefSeq

6
UniProt

3
CCDS

CCDS37167.1

Ensembl

ENSMUSG00000022438 (Evidence)
NCBI Gene

170736

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022438	Ensembl Gene Model \| MGI Sequence Detail	83646	C57BL/6J	± kb
transcript	ENSMUST00000023072	Ensembl \| MGI Sequence Detail	3784	Not Applicable
polypeptide	ENSMUSP00000023072	Ensembl \| MGI Sequence Detail	365	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012304 beta-parvin

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR028433 Parvin
GlyGen

Q9ES46 1 site, 1 O-linked glycan (1 site)

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All nucleic 54

Genomic 1

cDNA 53

Microarray probesets 3

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MGI:2146041, MGI:2146245, MGI:2429856

Summaries

All 77

Developmental Gene Expression 8

Diseases 1

Gene Ontology 12

Phenotypes 38
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Parvb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132451	Chr15:84116231-84116242 (+)	-7 bp
Tssr132452	Chr15:84116251-84116277 (+)	20 bp
Tssr132453	Chr15:84116294-84116310 (+)	58 bp
Tssr132454	Chr15:84141328-84141352 (+)	25,096 bp
Tssr132455	Chr15:84141362-84141373 (+)	25,124 bp
Tssr132456	Chr15:84182343-84182346 (+)	66,101 bp
Tssr4674	Chr15:84185663-84185669 (+)	69,422 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24